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基于蛋白质/多糖的水凝胶负载益生菌介导的治疗系统:综述

Protein/polysaccharide-based hydrogels loaded probiotic-mediated therapeutic systems: A review.

作者信息

Zheng Bing-De, Gan Lei, Tian Li-Yuan, Chen Guan-Hong

机构信息

College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.

College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.

出版信息

Int J Biol Macromol. 2023 Dec 31;253(Pt 2):126841. doi: 10.1016/j.ijbiomac.2023.126841. Epub 2023 Sep 9.

Abstract

The natural characteristics of protein/polysaccharide-based hydrogels, as a potential drug delivery platform, have attracted extensive attention. Probiotics have attracted renewed interest in drug research because of their beneficial effects on host health. The idea of using probiotics loaded on protein/polysaccharide-based hydrogels as potential drugs to treat different diseases has been put forward and shows great prospects. Based on this, in this review, we highlight the design strategy of hydrogels loaded probiotic-mediated therapy systems and review the potential diseases that have been proved to be treatable in the laboratory, including promoting wound healing and improving intestinal health and vaginal health, and discuss the challenges existing in the current design.

摘要

基于蛋白质/多糖的水凝胶作为一种潜在的药物递送平台,其天然特性已引起广泛关注。益生菌因其对宿主健康的有益作用而在药物研究中重新引起了人们的兴趣。将负载于蛋白质/多糖基水凝胶上的益生菌作为治疗不同疾病的潜在药物的想法已经被提出,并显示出巨大的前景。基于此,在本综述中,我们重点介绍了负载益生菌的水凝胶介导治疗系统的设计策略,并回顾了在实验室中已被证明可治疗的潜在疾病,包括促进伤口愈合、改善肠道健康和阴道健康,并讨论了当前设计中存在的挑战。

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