Wickramasinghe S N, Gill D S, Broom G N, Akinyanju O O, Grange A
Scand J Haematol. 1985 Sep;35(3):292-8. doi: 10.1111/j.1600-0609.1985.tb01708.x.
26 of 46 Nigerian children with protein-energy malnutrition (PEM) had elevated S-Ferritin levels; the geometric mean value in the entire group of children with PEM was 146 micrograms/l and the observed range 11-7000 micrograms/l. There was no statistically significant correlation between the logarithm of the S-Ferritin level and the amount of stainable iron in marrow fragments (r = 0.23; p greater than 0.2). A stepwise multiple linear regression analysis in which the logarithm of the S-Ferritin level was used as the dependent variable and a total of 17 clinical, biochemical and haematological parameters were used as the independent variables showed that 34.8% of the variability in S-Ferritin could be accounted for by variations in the percentage of lymphocytes in the bone marrow. We speculate that the latter parameter may be an index of previous infection and that the elevated S-Ferritin levels may, therefore, be at least partly caused by infections. Increased serum aspartate transaminase activities were also encountered in PEM, suggesting that hepatocellular damage may contribute to the high S-Ferritin levels in this condition. Our data indicate that S-Ferritin has a limited value as an indicator of iron status in subjects with PEM, presumably because of the frequency of infections and of hepatocellular damage in such subjects.
46名患有蛋白质 - 能量营养不良（PEM）的尼日利亚儿童中有26名血清铁蛋白（S - Ferritin）水平升高；患有PEM的儿童全组几何平均值为146微克/升，观察范围为11 - 7000微克/升。S - Ferritin水平的对数与骨髓碎片中可染色铁的量之间无统计学显著相关性（r = 0.23；p＞0.2）。以S - Ferritin水平的对数作为因变量，总共17项临床、生化和血液学参数作为自变量进行逐步多元线性回归分析，结果显示S - Ferritin变异性的34.8%可由骨髓中淋巴细胞百分比的变化来解释。我们推测后一参数可能是既往感染的一个指标，因此，S - Ferritin水平升高可能至少部分是由感染引起的。PEM患者中还出现血清天冬氨酸转氨酶活性增加，提示肝细胞损伤可能导致这种情况下S - Ferritin水平升高。我们的数据表明，S - Ferritin作为PEM患者铁状态指标的价值有限，可能是因为此类患者感染和肝细胞损伤的发生率较高。
