Sunjin Clinical Research Center, Sunjin Beauty Science Co., Ltd., Seoul, South Korea.
Faculty of Life Sciences, University of Toronto, Toronto, Ontario, Canada.
Skin Res Technol. 2024 Oct;30(10):e70046. doi: 10.1111/srt.70046.
Ceramides are essential epidermal constituents that play a critical role in skin moisturization treatment as a raw material in cosmetics formulation. Recently, ceramides have been known to be frequently applied in various cosmetic formulations. Despite ceramide's beneficial characteristics, academic research regarding ceramides and their skin absorption remains insufficient. Therefore, our study conducted clinical research employing Raman spectroscopy to investigate the effects of ceramides on skin absorption to enhance the understanding of ceramides' dermatological functionality and their topical application in cosmetics science.
Twenty healthy individuals with dry skin have participated in this clinical trial. In this double-arm designed trial, the test group received an investigational product with ceramides (5000 ppm) and a control group received an investigational product without the ceramides while all other components remained identical. The subjects visited the clinical research center and acclimatized for 30 min in constant humidity and temperature for equilibrium, subsequently conducting a measurement. Before the trial, the research subject's target site (lower arm area) was kept clean, devoid of any cosmetic administering 24 h before the trial when investigational product was topically applied.
Our findings with Raman spectroscopy statistically demonstrate that skin absorption amount, speed and depth for both groups improved overall (p < 0.05) after administration of the investigational product. Notably, the test group received an investigational product with ceramides (5000 ppm) indicating superior effectiveness across all parameters compared to a control group from comparison analysis of each parameter (p < 0.05).
This study concludes that ceramide-containing cosmetics provide a beneficial effect on skin absorption via visual and statistical results of Raman spectroscopy analysis.
神经酰胺是表皮的重要组成部分，作为化妆品配方中的原料，在皮肤保湿处理中起着关键作用。最近，神经酰胺已被广泛应用于各种化妆品配方中。尽管神经酰胺具有有益的特性，但关于神经酰胺及其皮肤吸收的学术研究仍然不足。因此，我们进行了一项临床研究，采用拉曼光谱法研究神经酰胺对皮肤吸收的影响，以增强对神经酰胺的皮肤功能的理解，并将其应用于化妆品科学。
本临床试验共纳入 20 名干性皮肤的健康个体。在这项双臂设计的试验中，试验组接受含有 5000ppm 神经酰胺的研究产品，对照组接受不含神经酰胺的研究产品，同时其他成分保持一致。受试者前往临床研究中心，在恒定的湿度和温度下适应 30 分钟以达到平衡，然后进行测量。在试验前，研究对象的目标部位（小臂区域）保持清洁，无任何化妆品。试验前 24 小时，将研究产品局部涂抹于目标部位。
拉曼光谱的结果统计表明，两组的皮肤吸收量、速度和深度均有整体改善（p<0.05）。值得注意的是，与对照组相比，试验组（含 5000ppm 神经酰胺）的所有参数均显示出更优的效果（p<0.05）。
本研究通过拉曼光谱分析的直观和统计结果得出结论，含神经酰胺的化妆品对皮肤吸收具有有益的效果。
