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Epigenetic modifiers: catalytic or noncatalytic, that is the question.

作者信息

Liu Yimin, Li Haitao

机构信息

State Key Laboratory of Molecular Oncology, Beijing Frontier Research Center for Biological Structure, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, China.

SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, 030001, China.

出版信息

Front Med. 2024 Oct;18(5):941-943. doi: 10.1007/s11684-024-1104-4. Epub 2024 Sep 28.

DOI:10.1007/s11684-024-1104-4
PMID:39333446
Abstract
摘要

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2
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.CBP 和 Gcn5 通过其催化活性以外的途径独立驱动合子基因组激活。
Sci Adv. 2023 Apr 21;9(16):eadf2687. doi: 10.1126/sciadv.adf2687.
3
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription.表观遗传分子伴侣：组蛋白修饰酶在转录调控中的无催化活性依赖功能。
Sci Adv. 2023 Apr 21;9(16):eadg6593. doi: 10.1126/sciadv.adg6593.
4
knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals.敲除斑马鱼是可行且可育的：不同脊椎动物中Setd2和组蛋白H3K36三甲基化对差异和发育应激的相关需求。
Cell Discov. 2020 Oct 20;6:72. doi: 10.1038/s41421-020-00203-8. eCollection 2020.
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.由Trr和哺乳动物类COMPASS蛋白在增强子处催化的组蛋白H3K4单甲基化对于发育和生存能力而言并非必需。
Nat Genet. 2017 Nov;49(11):1647-1653. doi: 10.1038/ng.3965. Epub 2017 Oct 2.
6
Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock.胚胎发育时间、轴向干细胞、染色质动力学与Hox时钟。
Genes Dev. 2017 Jul 15;31(14):1406-1416. doi: 10.1101/gad.303123.117.
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H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity.H3K36甲基化通过增强转录保真度调控酿酒酵母中的营养应激反应。
Cell Rep. 2017 Jun 13;19(11):2371-2382. doi: 10.1016/j.celrep.2017.05.057.
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Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.Mll3和Mll4促进增强子RNA合成及启动子转录，且不依赖于H3K4单甲基化。
Mol Cell. 2017 May 18;66(4):568-576.e4. doi: 10.1016/j.molcel.2017.04.018. Epub 2017 May 5.
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