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今天无痛,明天虚弱:一例因滥用双氯芬酸导致的电解质紊乱。

Pain-free today, weak tomorrow: a case of electrolyte disorder due to diclofenac misuse.

机构信息

Department of Public Health, Chair of Nephrology, University Federico II of Naples, Via Pansini 5, Naples, 80131, Italy.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, via Pansini,5, Naples, 80131, Italy.

出版信息

BMC Nephrol. 2024 Sep 27;25(1):317. doi: 10.1186/s12882-024-03759-9.

DOI:10.1186/s12882-024-03759-9
PMID:39333987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11428913/
Abstract

BACKGROUND

The nephrotoxic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are widely acknowledged. In particular, diclofenac is the most commonly prescribed NSAIDs, but no previous findings of electrolyte disturbances were reported following its administration.

CASE REPORT

We presented the case of a man who experienced significant weakness associated with severe deficiencies in potassium, calcium, and magnesium after misusing diclofenac because of severe back pain.

CONCLUSIONS

This case emphasizes the need of awareness about the electrolyte imbalances and electrolyte disturbances associated with the misuse of diclofenac, which is a widely available drug. This is a case report which does not need a Clinical Trial Number.

摘要

背景

非甾体抗炎药(NSAIDs)的肾毒性作用是众所周知的。特别是,双氯芬酸是最常被开的 NSAIDs,但在使用后没有发现电解质紊乱的先前发现。

病例报告

我们报告了一例因严重背痛滥用双氯芬酸后出现严重低钾、低钙和低镁相关显著无力的病例。

结论

本病例强调了对与滥用双氯芬酸相关的电解质失衡和电解质紊乱的认识的必要性,因为双氯芬酸是一种广泛使用的药物。这是一个病例报告,不需要临床试验编号。

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Pain-free today, weak tomorrow: a case of electrolyte disorder due to diclofenac misuse.今天无痛,明天虚弱:一例因滥用双氯芬酸导致的电解质紊乱。
BMC Nephrol. 2024 Sep 27;25(1):317. doi: 10.1186/s12882-024-03759-9.
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本文引用的文献

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Determination of efficacy and toxicity of diclofenac microemulsion formulation for musculoskeletal pain: an observational study.双氯芬酸微乳制剂治疗肌肉骨骼疼痛的疗效和毒性的测定:一项观察性研究。
BMC Res Notes. 2020 Jun 12;13(1):285. doi: 10.1186/s13104-020-05120-3.
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Impaired consciousness, hypokalaemia and renal tubular acidosis in sustained Nurofen Plus abuse.长期滥用诺福丁复合制剂导致意识障碍、低钾血症和肾小管酸中毒。
BMJ Case Rep. 2019 Nov 27;12(11):e231403. doi: 10.1136/bcr-2019-231403.
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Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats.维生素C和维生素E对双氯芬酸钠中毒大鼠的药理作用
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Electrolyte and Acid-base disturbances associated with non-steroidal anti-inflammatory drugs.与非甾体抗炎药相关的电解质和酸碱紊乱
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Diclofenac induced acute renal failure in a decompensated elderly patient.双氯芬酸导致一名失代偿老年患者出现急性肾衰竭。
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Action of diclofenac on kidney mitochondria and cells.双氯芬酸对肾脏线粒体和细胞的作用。
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Selective cyclooxygenase-2 inhibitors: a pattern of nephrotoxicity similar to traditional nonsteroidal anti-inflammatory drugs.选择性环氧化酶-2抑制剂:一种与传统非甾体抗炎药相似的肾毒性模式。
Am J Med. 2001 Jul;111(1):64-7. doi: 10.1016/s0002-9343(01)00757-4.
9
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death.双氯芬酸诱导的体内肾毒性可能涉及氧化应激介导的大量基因组DNA片段化和凋亡性细胞死亡。
Free Radic Biol Med. 2001 Jul 15;31(2):139-52. doi: 10.1016/s0891-5849(01)00560-3.
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Mechanism of action of anti-inflammatory drugs.抗炎药物的作用机制。
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