Bioinformatics Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
J Transl Med. 2024 Sep 27;22(1):869. doi: 10.1186/s12967-024-05672-z.
The health benefits of the Mediterranean diet are partially attributed to the polyphenols present in extra virgin olive oil (EVOO), which have been shown to have anti-cancer properties. However, the possible effect that EVOO could have on Chronic Lymphocytic Leukemia (CLL) has not been fully explored.
This study investigates the anti-CLL activity of EVOO through a computational multi-level data analysis procedure, focusing on the identification of shared biological functions between them. Specifically, publicly available data from genomics, transcriptomics and proteomics related to EVOO consumption and CLL were collected from several resources and analyzed through a computational pipeline, highlighting common molecular mechanisms and biological processes. Computational verification of a number of the highlighted functional terms associating CLL and EVOO has been performed as well.
Our investigation revealed four molecular pathways and three biological processes that overlap between mechanisms associated with CLL and those impacted by the consumption of EVOO. To further investigate the common biological functions, we focused on AKT1-related terms, aiming to investigate the potential importance of AKT1 in the anti- CLL effects associated with EVOO.
Overall, the results provide valuable insights into the potential beneficial effect of EVOO in CLL and highlight EVOO's bioactive compounds as promising candidates for future investigations.
地中海饮食的健康益处部分归因于特级初榨橄榄油（EVOO）中存在的多酚，这些多酚已被证明具有抗癌特性。然而，EVOO 对慢性淋巴细胞白血病（CLL）可能产生的影响尚未得到充分探索。
本研究通过计算多层次数据分析程序研究 EVOO 的抗 CLL 活性，重点是识别它们之间的共享生物学功能。具体来说，从多个资源中收集与 EVOO 消费和 CLL 相关的基因组学、转录组学和蛋白质组学的公开可用数据，并通过计算管道进行分析，突出常见的分子机制和生物学过程。还对与 CLL 和 EVOO 相关的功能术语进行了计算验证。
我们的研究揭示了与 CLL 相关的机制与 EVOO 消费所影响的机制之间重叠的四个分子途径和三个生物学过程。为了进一步研究共同的生物学功能，我们专注于 AKT1 相关术语，旨在研究 AKT1 在与 EVOO 相关的抗 CLL 作用中的潜在重要性。
总的来说，这些结果为 EVOO 在 CLL 中的潜在有益作用提供了有价值的见解，并强调了 EVOO 的生物活性化合物作为未来研究的有前途的候选物。
