Chen Desheng, Chen Zeping, Yuan Jiabin, Chen Guanzi, Chen Yutao, He Kaiming, Hu Yongwei, Ye Linsen, Yang Yang
Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Stem Cell Res Ther. 2025 May 28;16(1):259. doi: 10.1186/s13287-025-04379-2.
Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have gained significant attention for their potential in cellular regeneration and functional rehabilitation. Nevertheless, the rapid expansion of research in this field makes it challenging for emerging trends and strategic priorities, potentially impeding scientific advancement. This study employs bibliometric analysis to systematically evaluate the research landscape and highlight pivotal research trajectories of hUCMSC-Exos.
Publications on hUCMSC-Exos from 2012 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Quantitative bibliometric analysis was implemented through integrated utilization of VOSviewer, CiteSpace, and Bibliometrix analytical tools.
China and its institutions led global publication output, with Qian Hui from Jiangsu University identified as the most prolific author. STEM CELL RESEARCH & THERAPY emerged as a high-impact journal in this domain. Current research predominantly focuses on immunomodulation, regenerative medicine, pharmaceutical delivery systems, and clinical model development. Future research directions are expected to explore angiogenesis, spinal cord injury, and immunomodulation.
This study maps the evolving landscape of hUCMSC-Exos research, emphasizing its applications in regenerative medicine. By synthesizing current and emerging paradigms, these findings provide insights into therapeutic potential, novel mechanisms, and pathways for clinical translation.
人脐带间充质干细胞衍生外泌体（hUCMSC-Exos）因其在细胞再生和功能康复方面的潜力而备受关注。然而，该领域研究的迅速扩展使得把握新兴趋势和战略重点具有挑战性，可能会阻碍科学进步。本研究采用文献计量分析方法，系统评估hUCMSC-Exos的研究态势，并突出关键研究轨迹。
从科学网核心合集（WoSCC）中检索2012年至2024年关于hUCMSC-Exos的出版物。通过综合运用VOSviewer、CiteSpace和Bibliometrix分析工具进行定量文献计量分析。
中国及其机构在全球出版物产出方面领先，江苏大学的钱晖被确定为发文量最多的作者。《干细胞研究与治疗》成为该领域的高影响力期刊。当前研究主要集中在免疫调节、再生医学、药物递送系统和临床模型开发。未来的研究方向预计将探索血管生成、脊髓损伤和免疫调节。
本研究描绘了hUCMSC-Exos研究的演变态势，强调了其在再生医学中的应用。通过综合当前和新兴范式，这些发现为治疗潜力、新机制以及临床转化途径提供了见解。
