Rajan Pradeep Kumar, Udoh Utibe-Abasi S, Finley Robert, Pierre Sandrine V, Sanabria Juan
Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Department of Surgery, School of Medicine, Marshall University, Huntington, WV 25701, USA.
Biomedicines. 2024 Aug 29;12(9):1961. doi: 10.3390/biomedicines12091961.
Circadian rhythms are endogenous behavioral or physiological cycles that are driven by a daily biological clock that persists in the absence of geophysical or environmental temporal cues. Circadian rhythm-related genes code for clock proteins that rise and fall in rhythmic patterns driving biochemical signals of biological processes from metabolism to physiology and behavior. Clock proteins have a pivotal role in liver metabolism and homeostasis, and their disturbances are implicated in various liver disease processes. Encoded genes play critical roles in the initiation and progression of metabolic dysfunction-associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC) and their proteins may become diagnostic markers as well as therapeutic targets. Understanding molecular and metabolic mechanisms underlying circadian rhythms will aid in therapeutic interventions and may have broader clinical applications. The present review provides an overview of the role of the liver's circadian rhythm in metabolic processes in health and disease, emphasizing MASH progression and the oncogenic associations that lead to HCC.
昼夜节律是内源性行为或生理周期，由日常生物钟驱动，该生物钟在没有地球物理或环境时间线索的情况下依然存在。与昼夜节律相关的基因编码时钟蛋白，这些蛋白以节律模式上升和下降，驱动从新陈代谢到生理和行为的生物过程的生化信号。时钟蛋白在肝脏代谢和内环境稳态中起关键作用，其紊乱与各种肝脏疾病过程有关。编码基因在代谢功能障碍相关脂肪性肝炎（MASH）向肝细胞癌（HCC）的发生和发展中起关键作用，其蛋白质可能成为诊断标志物和治疗靶点。了解昼夜节律背后的分子和代谢机制将有助于治疗干预，并可能具有更广泛的临床应用。本综述概述了肝脏昼夜节律在健康和疾病代谢过程中的作用，重点强调了MASH的进展以及导致HCC的致癌关联。
