Cranwell P D
Br J Nutr. 1985 Jul;54(1):305-20. doi: 10.1079/bjn19850113.
The development of gastric secretory capacity of hydrochloric acid and pepsin (EC 3.4.23.1) was studied in thirty-eight Large White X Landrace pigs from the litters of six sows (three pairs of two), 9-38 d of age. The pigs of each pair of sows were born within 24 h of each other. The pigs of a litter were paired according to sex and size and cross-fostered, i.e. one pig from each pair was allocated to each sow. One litter from each pair was reared entirely by the sow (milk-fed, MF) whereas the other litter was reared by the sow for 21 d, but was allowed access to solid food (210 g crude protein (nitrogen X 6.25)/kg) at 12 d and was entirely dependent on solid food after 21 d (creep-fed, CF). Following a 14-18 h fast, pigs were anaesthetized (Halothane-sodium pentobarbitone) and their stomachs perfused at a constant rate with Ringer solution. Gastric secretion was stimulated by intravenous infusion of betazole hydrochloride (Histalog) at 3 mg/kg per h for 2 h. Hydrochloric acid and pepsin were measured in the perfusate which was collected at 15-min intervals. There were significant positive correlations between stomach weight and body-weight for both MF and CF pigs. The slope of the regression line for CF pigs was significantly greater than that for MF pigs (P less than 0.01). There were significant positive correlations between maximal acid output and stomach weight for both MF and CF pigs. There were significant positive correlations between maximal pepsin output and stomach weight for both MF and CF pigs. The slope of the regression line for CF pigs was significantly different from that for MF pigs (P less than 0.01). There were also significant positive correlations between maximal pepsin output per unit stomach weight and stomach weight for both MF and CF pigs. The pattern of development of pepsin secretory capacity in both CF and MF pigs was different from that for acid secretion. Maximal outputs of acid per unit stomach weight for MF and CF pigs remained relatively constant. Maximal outputs of pepsin per unit stomach weight and per unit body-weight increased with age for both MF and CF pigs. The results indicate that pigs given access to solid food before weaning and weaned on to solid food have heavier stomachs and greater acid and pepsin secretory capacity than pigs fed entirely on sows' milk.
对来自6头母猪（3对，每对2头）窝中的38头大白猪×长白猪杂交仔猪进行了研究，研究其9至38日龄时盐酸和胃蛋白酶（EC 3.4.23.1）胃分泌能力的发育情况。每对母猪所产仔猪在彼此24小时内出生。一窝仔猪按性别和大小配对并进行交叉寄养，即每对中的一头仔猪分配给每头母猪。每对中的一窝仔猪完全由母猪饲养（全乳喂养，MF），而另一窝仔猪由母猪饲养21天，但在12日龄时可接触固体食物（210克粗蛋白（氮×6.25）/千克），21日龄后完全依赖固体食物（早期断奶补饲，CF）。禁食14 - 18小时后，仔猪麻醉（氟烷 - 戊巴比妥钠），用林格氏液以恒定速率灌注其胃。通过静脉输注盐酸倍他唑（组胺甲磺酸盐）以3毫克/千克每小时的速度持续2小时来刺激胃分泌。每隔15分钟收集灌注液并测定其中的盐酸和胃蛋白酶含量。MF和CF仔猪的胃重量与体重之间均存在显著正相关。CF仔猪回归线的斜率显著大于MF仔猪（P < 0.01）。MF和CF仔猪的最大酸分泌量与胃重量之间均存在显著正相关。MF和CF仔猪的最大胃蛋白酶分泌量与胃重量之间均存在显著正相关。CF仔猪回归线的斜率与MF仔猪显著不同（P < 0.01）。MF和CF仔猪每单位胃重量的最大胃蛋白酶分泌量与胃重量之间也存在显著正相关。CF和MF仔猪胃蛋白酶分泌能力的发育模式与酸分泌不同。MF和CF仔猪每单位胃重量的最大酸分泌量保持相对恒定。MF和CF仔猪每单位胃重量和每单位体重的最大胃蛋白酶分泌量均随年龄增加。结果表明，断奶前接触固体食物并断奶后食用固体食物的仔猪比完全以母乳为食的仔猪胃更重，酸和胃蛋白酶分泌能力更强。
