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断奶仔猪肠道屏障完整性的营养调控

Nutritional Regulation of Gut Barrier Integrity in Weaning Piglets.

作者信息

Modina Silvia Clotilde, Polito Umberto, Rossi Raffaella, Corino Carlo, Di Giancamillo Alessia

机构信息

Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Via Celoria, 10, 20133 Milan, Italy.

Department of Veterinary Medicine, Università degli Studi di Milano, Via Celoria, 10, 20133 Milan, Italy.

出版信息

Animals (Basel). 2019 Nov 29;9(12):1045. doi: 10.3390/ani9121045.

DOI:10.3390/ani9121045
PMID:31795348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6940750/
Abstract

Weaning is very stressful for piglets and leads to alterations in the intestinal barrier, a reduction in nutrient absorption and a higher susceptibility to intestinal diseases with heavy economic losses. This review describes the structures involved in the intestinal barrier: the epithelial barrier, immune barrier and the enteric nervous system. Here, new insights into the interactions between feed components and the physiology and morphology of the epithelial barrier are highlighted. Dietary strategies focused on improving gut health are also described including amino acids, phytochemicals and organic acids.

摘要

断奶对仔猪来说压力很大,会导致肠道屏障改变、营养吸收减少,以及对肠道疾病的易感性增加,造成巨大经济损失。本综述描述了肠道屏障所涉及的结构:上皮屏障、免疫屏障和肠神经系统。本文重点介绍了饲料成分与上皮屏障的生理学和形态学之间相互作用的新见解。还介绍了专注于改善肠道健康的日粮策略,包括氨基酸、植物化学物质和有机酸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b36/6940750/f411c3ee91dd/animals-09-01045-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b36/6940750/08b87fbcf3cc/animals-09-01045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b36/6940750/f411c3ee91dd/animals-09-01045-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b36/6940750/08b87fbcf3cc/animals-09-01045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b36/6940750/f411c3ee91dd/animals-09-01045-g002.jpg

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Front Vet Sci. 2019 Feb 21;6:46. doi: 10.3389/fvets.2019.00046. eCollection 2019.
2
Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets.胃内灌注短链脂肪酸可改善断奶仔猪的肠道屏障功能。
Genes Nutr. 2019 Feb 1;14:4. doi: 10.1186/s12263-019-0626-x. eCollection 2019.
3
Dietary Verbascoside Influences Gut Morphology and the Expression of α-Transducin and α-Gustducin in the Small Intestine of Weaned Piglets Exposed to n-6 Polyunsaturated Fatty Acids-Induced Oxidative Stress.
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Vet Q. 2025 Dec;45(1):1-15. doi: 10.1080/01652176.2024.2447600. Epub 2025 Jan 3.
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Crude Blueberry Phenolic Extracts Improve Gut Barrier Integrity and Exert Anti-Inflammatory and Antimicrobial Activity in an In Vitro Weaning Stress Model.粗制蓝莓酚类提取物可改善肠道屏障完整性,并在体外断奶应激模型中发挥抗炎和抗菌活性。
Antioxidants (Basel). 2024 Aug 28;13(9):1044. doi: 10.3390/antiox13091044.
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An Updated Review of Emerging Sources of Selenium in Weaned Piglet Nutrition.断奶仔猪营养中硒的新来源最新综述
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