Ying Li, MD, The Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University. 37 Guoxuexiang, Chengdu, Sichuan providence, PR. China, 610041; Tel: 86-028-8542 2321; Fax: 86-028-8542 2321; E-mail:
J Nutr Health Aging. 2021;25(2):197-200. doi: 10.1007/s12603-020-1481-6.
Older adults with frailty are vulnerable to cardiovascular event and subsequent mortality. Frailty and albuminuria share atherosclerotic risk factors. The present study investigated the association of frailty and albuminuria among elderly Chinese inpatients.
Cross-sectional study.
A total of 202 patients aged over 60 years from the Center of Gerontology and Geriatric, West China Hospital.
Frailty was defined using the five-item FRAIL scale. This included measurements of fatigue, resistance, ambulation, illness, and loss of weight. We further determined the random urine albumin/creatinine ratio (UACR) of all patients. Random UACR ≥30 mg/g was defined as albuminuria, and < 30mg/g as normoalbuminuria. The relationship between albuminuria and frailty was assessed through multiple regression analysis.
The 202 participants (156 men, 77.2%) had an average age of 78.99±7.60 years, which ranged from 60 to 95. Compared to those without albuminuria, elderly patients with albuminuria were of an older age, had a higher prevalence of diabetes and poorer renal function. The prevalence of frailty, pre-frailty and ambulation (one of the FRAIL components) were higher in the albuminuria group than the normoalbuminuria group (23.9% vs. 12.2%, 47.9% vs.37.4%, 33.8% vs. 16.0%, respectively, P<0.05). Following the adjustment for age, eGFR, hypertension, diabetes and using ACEI/ARB, being frail or pre-frail led to an enhanced risk of albuminuria (OR frail 2.60, 95% CI frail 1.01-6.72; OR pre-frail 2.14, 95% CI pre-frail 1.03-4.44).
Frailty is independently associated with albuminuria when adjusted for classic cardiovascular risk factors.
虚弱的老年人易发生心血管事件和随后的死亡。虚弱和白蛋白尿共享动脉粥样硬化的危险因素。本研究调查了中国老年住院患者中虚弱和白蛋白尿之间的关系。
横断面研究。
共有来自华西医院老年医学中心的 202 名年龄在 60 岁以上的患者。
使用五分量表 FRAIL 量表定义虚弱。这包括疲劳、抵抗力、步行、疾病和体重减轻的测量。我们进一步确定了所有患者的随机尿白蛋白/肌酐比值（UACR）。随机 UACR≥30mg/g 定义为白蛋白尿，<30mg/g 为正常白蛋白尿。通过多元回归分析评估白蛋白尿与虚弱之间的关系。
202 名参与者（男性 156 名，占 77.2%）的平均年龄为 78.99±7.60 岁，年龄范围为 60 至 95 岁。与无白蛋白尿者相比，有白蛋白尿的老年患者年龄较大，糖尿病患病率较高，肾功能较差。白蛋白尿组的虚弱、衰弱前期和步行能力（FRAIL 组成部分之一）的患病率高于正常白蛋白尿组（分别为 23.9%比 12.2%、47.9%比 37.4%、33.8%比 16.0%，P<0.05）。在校正年龄、eGFR、高血压、糖尿病和使用 ACEI/ARB 后，虚弱或衰弱前期导致白蛋白尿的风险增加（虚弱的 OR 为 2.60，95%CI 为 1.01-6.72；衰弱前期的 OR 为 2.14，95%CI 为 1.03-4.44）。
在调整经典心血管危险因素后，虚弱与白蛋白尿独立相关。
