Hammersley M S, Holland M R, Walford S, Thorn P A
Br Med J (Clin Res Ed). 1985 Nov 9;291(6505):1330-2. doi: 10.1136/bmj.291.6505.1330.
The annual rate at which patients defaulted from follow up at the Wolverhampton diabetic clinic between 1971 and 1981 was 4.1% overall and 3.5% in white patients. In 1982 a study was started to discover what happened to white patients, born after 1919, who defaulted from the hospital clinic. There were 162 defaulters, of whom 19 had died. Of the remaining 143 patients, 19 were attending another hospital diabetic clinic, 22 had moved out of the area, and 28 refused to participate in the study. Seventy four agreed to participate: 39 were treated with diet, 15 with oral hypoglycaemic agents, and 20 with insulin. They were matched for sex, age, treatment, and duration of diabetes with patients attending the clinic. Non-insulin dependent defaulters were significantly more overweight at diagnosis (40% v 25%; p less than 0.05) and remained more obese. They developed significantly higher diastolic blood pressure (94 v 86 mm Hg; p less than 0.02) and higher haemoglobin A1 (HbA1) concentrations (11.7% v 8.4%; p less than 0.01). They had significantly more neuropathy at reassessment (15 v 6 out of 54; p less than 0.05) and a greater incidence of new retinopathy (p less than 0.02), which correlated with their higher diastolic blood pressures (p less than 0.01) and HbA1 concentration (p less than 0.02). In defaulters who were treated with insulin only the prevalence of neuropathy was significantly different from that in controls (p less than 0.05). Defaulters received minimal medical supervision and suffered greater morbidity than regular attenders at the clinic.
1971年至1981年间,伍尔弗汉普顿糖尿病诊所患者的年度失访率总体为4.1%,白人患者为3.5%。1982年开展了一项研究,以了解1919年以后出生、在医院诊所失访的白人患者的情况。共有162名失访者,其中19人已死亡。在其余143名患者中,19人在另一家医院的糖尿病诊所就诊,22人已搬离该地区,28人拒绝参与研究。74人同意参与:39人接受饮食治疗,15人接受口服降糖药治疗,20人接受胰岛素治疗。他们在性别、年龄、治疗方式和糖尿病病程方面与在诊所就诊的患者进行了匹配。非胰岛素依赖型失访者在诊断时明显超重(40%对25%;p<0.05),且仍更为肥胖。他们的舒张压明显更高(94对86毫米汞柱;p<0.02),血红蛋白A1(HbA1)浓度更高(11.7%对8.4%;p<0.01)。重新评估时,他们的神经病变明显更多(54人中15人对6人;p<0.05),新视网膜病变的发生率更高(p<0.02),这与他们较高的舒张压(p<0.01)和HbA1浓度(p<0.02)相关。仅接受胰岛素治疗的失访者中神经病变的患病率与对照组有显著差异(p<0.05)。失访者接受的医疗监督极少,且比诊所的定期就诊者发病率更高。