Zhang Xubo, Zhang Qian, Song Xiaoxuan, Yang Wanchen, Cheng Andi, Zhang Jianzhen, Dong Wei
Shanxi Key Laboratory of Nucleic Acid Biopesticides, Research Institute of Applied Biology, Shanxi University, Taiyuan 030006, China.
Insects. 2024 Sep 14;15(9):703. doi: 10.3390/insects15090703.
Potassium sorbate (PS) is a preservative widely used in the food, pharmaceutical, and cosmetics industries. Improper and careless use of PS can lead to various health issues and potential environmental problems. is capable of making rapid and sensitive responses to stress or other stimuli. Here we utilized as a model organism to evaluate the potential toxicity of PS. Our study revealed that PS ingestion reduced the lifespan and fecundity of . In addition, excessive PS ingestion led to cell apoptosis and ROS accumulation in the midgut. Furthermore, PS intake also enhanced the mitophagy of midgut cells. Strikingly, PS affected the cell differentiation progression as well, leading to the production of more enteroendocrine (EE) cells. We further demonstrated that the expression of notch (N), a vital player in intestinal stem cell (ISC) differentiation, was down-regulated in the midgut. This indicates that the differentiation progression was affected potentially by repressing the N expression.
山梨酸钾（PS）是一种广泛应用于食品、制药和化妆品行业的防腐剂。不当和粗心使用PS会导致各种健康问题和潜在的环境问题。 能够对压力或其他刺激做出快速而敏感的反应。在这里，我们利用 作为模式生物来评估PS的潜在毒性。我们的研究表明，摄入PS会缩短 的寿命并降低其繁殖力。此外，过量摄入PS会导致中肠细胞凋亡和活性氧积累。此外，摄入PS还会增强中肠细胞的线粒体自噬。引人注目的是，PS也影响细胞分化进程，导致产生更多的肠内分泌（EE）细胞。我们进一步证明，在中肠中，肠道干细胞（ISC）分化的关键因子Notch（N）的表达下调。这表明分化进程可能受到N表达抑制的影响。
