A-Allele as a Biomarker for Periodontitis Severity in Bulgarian Patients.

BACKGROUND

Periodontitis is a complex disease, and bacterial factors play a crucial role in its initiation. The contributions of genetic and epigenetic factors to the pathogenesis of periodontal disease are increasingly recognized. Single-nucleotide polymorphisms (SNPs) in various molecules, including cytokines, are of particular interest due to their established involvement in numerous diseases. This study investigates the influence of SNPs in the gene at positions and (also referred to as ) on the severity of periodontitis in a cohort of Bulgarian patients.

METHODS

In the recent study, both clinical and paraclinical methodologies were employed to comprehensively assess the periodontal status of the participants. The genotypic characterization of polymorphisms was performed by PCR RFLP analysis. Statistical analyses, including principal component analysis (PCA), were executed utilizing IBM SPSS Statistics Version 21.

RESULTS

We have established a statistically significant association between the presence of at least one A-allele in the patients' genotype and the incidence of severe periodontitis ( = 0.047).

CONCLUSIONS

single-nucleotide polymorphisms (SNPs) could be effectively considered as biomarkers for the severity of periodontitis.