Department of Periodontology, Faculty of Dental Medicine, Medical University of Sofia, 1000 Sofia, Bulgaria.
National Genetic Laboratory, University Hospital of Obstetrics, Medical University, 1000 Sofia, Bulgaria.
Genes (Basel). 2024 Sep 18;15(9):1221. doi: 10.3390/genes15091221.
Periodontitis is a complex disease, and bacterial factors play a crucial role in its initiation. The contributions of genetic and epigenetic factors to the pathogenesis of periodontal disease are increasingly recognized. Single-nucleotide polymorphisms (SNPs) in various molecules, including cytokines, are of particular interest due to their established involvement in numerous diseases. This study investigates the influence of SNPs in the gene at positions and (also referred to as ) on the severity of periodontitis in a cohort of Bulgarian patients.
In the recent study, both clinical and paraclinical methodologies were employed to comprehensively assess the periodontal status of the participants. The genotypic characterization of polymorphisms was performed by PCR RFLP analysis. Statistical analyses, including principal component analysis (PCA), were executed utilizing IBM SPSS Statistics Version 21.
We have established a statistically significant association between the presence of at least one A-allele in the patients' genotype and the incidence of severe periodontitis ( = 0.047).
single-nucleotide polymorphisms (SNPs) could be effectively considered as biomarkers for the severity of periodontitis.
牙周炎是一种复杂的疾病，细菌因素在其发病中起着至关重要的作用。遗传和表观遗传因素在牙周病发病机制中的作用越来越受到重视。由于各种分子（包括细胞因子）中的单核苷酸多态性（SNPs）已被证实与许多疾病有关，因此它们尤其受到关注。本研究调查了保加利亚患者队列中 基因位置和 （也称为 ）的 SNPs 对牙周炎严重程度的影响。
在最近的研究中，采用临床和临床前方法学对参与者的牙周状况进行了全面评估。通过 PCR RFLP 分析对 多态性的基因型特征进行了分析。使用 IBM SPSS Statistics Version 21 进行了包括主成分分析（PCA）在内的统计分析。
我们已经确定了患者基因型中至少存在一个 A-等位基因与重度牙周炎的发生之间存在统计学显著关联（= 0.047）。
单核苷酸多态性（SNPs）可以被有效地视为牙周炎严重程度的生物标志物。
