Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja-shi 719-1197, Okayama, Japan.
Fundamental Laboratory, Ohayo Daily Products Co., Ltd., 565 Koshita, Naka-ku, Okayama-shi 703-8505, Okayama, Japan.
Int J Mol Sci. 2024 Sep 14;25(18):9934. doi: 10.3390/ijms25189934.
Obesity is a major global health concern. Studies suggest that the gut microflora may play a role in protecting against obesity. Probiotics, including lactic acid bacteria and , have garnered attention for their potential in obesity prevention. However, the effects of -fermented products on obesity have not been thoroughly elucidated. , which exists in the gut of animals, is known to enhance lipid metabolism. During fermentation, it produces acetic acid, which has been reported to improve glucose tolerance and insulin resistance, and exhibit anti-obesity and anti-diabetic effects. Functional foods have been very popular around the world, and fermented milk is a good candidate for enrichment with probiotics. In this study, we aim to evaluate the beneficial effects of milks fermented with strains on energy metabolism and obesity prevention. Three strains (Bif-15, Bif-30, and Bif-39), isolated from newborn human feces, were assessed for their acetic acid production and viability in milk. These strains were used to ferment milk. Otsuka-Long-Evans Tokushima Fatty (OLETF) rats administered Bif-15-fermented milk showed significantly lower weight gain compared to those in the water group. The phosphorylation of AMPK was increased and the expression of lipogenic genes was suppressed in the liver of rats given Bif-15-fermented milk. Additionally, gene expression related to respiratory metabolism was significantly increased in the soleus muscle of rats given Bif-15-fermented milk. These findings suggest that milk fermented with the strain Bif-15 can improve lipid metabolism and suppress obesity.
肥胖是一个全球性的健康问题。研究表明，肠道微生物群可能在预防肥胖方面发挥作用。益生菌，包括乳酸菌和 ，因其在预防肥胖方面的潜力而受到关注。然而， -发酵产品对肥胖的影响尚未得到充分阐明。 ，存在于动物的肠道中，已知能增强脂代谢。在发酵过程中，它会产生乙酸，据报道，乙酸能改善葡萄糖耐量和胰岛素抵抗，并表现出抗肥胖和抗糖尿病作用。功能性食品在世界各地都非常受欢迎，发酵乳是用益生菌强化的良好候选物。在这项研究中，我们旨在评估用 菌株发酵的牛奶对能量代谢和肥胖预防的有益作用。从新生人类粪便中分离出的三种 菌株（Bif-15、Bif-30 和 Bif-39），评估了它们在牛奶中的产乙酸能力和生存能力。这些菌株被用来发酵牛奶。与水组相比，给予 Bif-15 发酵乳的 Otsuka-Long-Evans Tokushima Fatty（OLETF）大鼠体重增加明显较低。Bif-15 发酵乳喂养的大鼠肝脏中 AMPK 的磷酸化增加，脂肪生成基因的表达受到抑制。此外，Bif-15 发酵乳喂养的大鼠比目鱼肌中与呼吸代谢相关的基因表达显著增加。这些发现表明，用 菌株 Bif-15 发酵的牛奶可以改善脂质代谢并抑制肥胖。
