Mariana Melissa, Cairrao Elisa
CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique s/n, 6200-506 Covilhã, Portugal.
FCS-UBI-Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.
Metabolites. 2023 Jun 11;13(6):746. doi: 10.3390/metabo13060746.
Since the beginning of their production, in the 1930s, phthalates have been widely used in the plastics industry to provide durability and elasticity to polymers that would otherwise be rigid, or as solvents in hygiene and cosmetic products. Taking into account their wide range of applications, it is easy to understand why their use has been increasing over the years, making them ubiquitous in the environment. This way, all living organisms are easily exposed to these compounds, which have already been classified as endocrine disruptor compounds (EDC), affecting hormone homeostasis. Along with this increase in phthalate-containing products, the incidence of several metabolic diseases has also been rising, namely diabetes. That said, and considering that factors such as obesity and genetics are not enough to explain this substantial increase, it has been proposed that the exposure to environmental contaminants may also be a risk factor for diabetes. Thus, the aim of this work is to review whether there is an association between the exposure to phthalates and the development of the several forms of diabetes mellitus, during pregnancy, childhood, and adulthood.
自20世纪30年代邻苯二甲酸盐开始生产以来，它们在塑料工业中被广泛使用，以使原本坚硬的聚合物具有耐久性和弹性，或作为卫生和化妆品中的溶剂。考虑到它们广泛的应用范围，很容易理解为什么这些年它们的使用一直在增加，使其在环境中无处不在。这样一来，所有生物都很容易接触到这些已被归类为内分泌干扰化合物（EDC）的化合物，从而影响激素稳态。随着含邻苯二甲酸盐产品的增加，几种代谢疾病的发病率也在上升，尤其是糖尿病。也就是说，考虑到肥胖和遗传等因素不足以解释这种大幅上升，有人提出接触环境污染物也可能是糖尿病的一个风险因素。因此，这项工作的目的是回顾在孕期、儿童期和成年期，接触邻苯二甲酸盐与几种糖尿病形式的发生之间是否存在关联。
