Generoso Diego, Martins Tatiane de Camargo, Camacho Camila Renata Corrêa, Segredo Manuella Pacífico de Freitas, Batah Sabrina Setembre, Fabro Alexandre Todorovic, Sciutto Edda, Fleury Agnès, Hamamoto Filho Pedro Tadao, Zanini Marco Antônio
Botucatu Medical School, UNESP-Universidade Estadual Paulista, Botucatu 18618-686, Brazil.
Ribeirão Preto Medical School, USP-Universidade de São Paulo, Ribeirão Preto 14049-900, Brazil.
Microorganisms. 2024 Sep 8;12(9):1860. doi: 10.3390/microorganisms12091860.
Oxidative stress is associated with several infectious diseases, as well as the severity of inflammatory reactions. The control of inflammation during parasite destruction is a target of neurocysticercosis treatment, as inflammation is strongly related to symptom severity. In this study, we investigated the presence of malondialdehyde and protein carbonyl, two by-products of reactive oxygen species (ROS), in an experimental model of extraparenchymal neurocysticercosis. Twenty male and twenty female rats were inoculated with 50 cysts of in the subarachnoid space of the cisterna magna. Ten animals (five males and five females) were used as controls. Three months after inoculation, their brains were harvested for oxidative stress and histological assessments. Infected animals had higher scores for inflammatory cell infiltrates, malondialdehyde, and protein carbonyl. These results encourage future efforts to monitor oxidative stress status in neurocysticercosis, particularly in the context of controlling inflammation.
氧化应激与多种传染病以及炎症反应的严重程度相关。在寄生虫破坏过程中控制炎症是神经囊尾蚴病治疗的一个目标，因为炎症与症状严重程度密切相关。在本研究中，我们在脑实质外神经囊尾蚴病的实验模型中研究了活性氧（ROS）的两种副产物丙二醛和蛋白质羰基的存在情况。将20只雄性和20只雌性大鼠在小脑延髓池蛛网膜下腔接种50个囊尾蚴。10只动物（5只雄性和5只雌性）用作对照。接种三个月后，取它们的大脑进行氧化应激和组织学评估。感染动物的炎症细胞浸润、丙二醛和蛋白质羰基得分更高。这些结果鼓励未来在神经囊尾蚴病中监测氧化应激状态方面做出努力，特别是在控制炎症的背景下。
