Szewczyk-Golec Karolina, Pawłowska Marta, Wesołowski Roland, Wróblewski Marcin, Mila-Kierzenkowska Celestyna
Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St, 85-092 Bydgoszcz, Poland.
Int J Mol Sci. 2021 May 27;22(11):5705. doi: 10.3390/ijms22115705.
is an apicomplexan parasite causing toxoplasmosis, a common disease, which is most typically asymptomatic. However, toxoplasmosis can be severe and even fatal in immunocompromised patients and fetuses. Available treatment options are limited, so there is a strong impetus to develop novel therapeutics. This review focuses on the role of oxidative stress in the pathophysiology and treatment of infection. Chemical compounds that modify redox status can reduce the parasite viability and thus be potential anti- drugs. On the other hand, oxidative stress caused by the activation of the inflammatory response may have some deleterious consequences in host cells. In this respect, the potential use of natural antioxidants is worth considering, including melatonin and some vitamins, as possible novel anti- therapeutics. Results of in vitro and animal studies are promising. However, supplementation with some antioxidants was found to promote the increase in parasitemia, and the disease was then characterized by a milder course. Undoubtedly, research in this area may have a significant impact on the future prospects of toxoplasmosis therapy.
是一种引起弓形虫病的顶复门寄生虫，弓形虫病是一种常见疾病，通常无症状。然而，弓形虫病在免疫功能低下的患者和胎儿中可能很严重甚至致命。现有的治疗选择有限，因此开发新型疗法的动力很强。本综述重点关注氧化应激在感染的病理生理学和治疗中的作用。改变氧化还原状态的化合物可以降低寄生虫的活力，从而成为潜在的抗寄生虫药物。另一方面，炎症反应激活引起的氧化应激可能对宿主细胞产生一些有害影响。在这方面，天然抗氧化剂的潜在用途值得考虑，包括褪黑素和一些维生素，作为可能的新型抗寄生虫疗法。体外和动物研究的结果很有前景。然而，发现补充一些抗氧化剂会促进寄生虫血症的增加，然后疾病表现为病程较轻。毫无疑问，该领域的研究可能对弓形虫病治疗的未来前景产生重大影响。
