Kodešová Tereza, Mašlejová Anna, Vlková Eva, Musilová Šárka, Horváthová Kristýna, Šubrtová Salmonová Hana
Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Prague, Czech Republic.
Microorganisms. 2024 Sep 11;12(9):1876. doi: 10.3390/microorganisms12091876.
is an emerging pathogen responsible for the serious foodborne disease, listeriosis. The commensal gut microbiota is the first line of defense against pathogen internalization. The gut microbiome can be modified by prebiotic substrates, which are frequently added to food products and dietary supplements. Prebiotics should selectively support the growth of beneficial microbes and thus improve host health. Nevertheless, little is known about their effect on the growth of . The aim of this study was to evaluate the growth ability of four strains, representing the most common serotypes, on prebiotic oligosaccharides (beta-(1,3)-D-glucan, inulin, fructooligosaccharides, galactooligosaccharides, lactulose, raffinose, stachyose and 2'-fucosyllactose and a mixture of human milk oligosaccharides) as a sole carbon source. The results showed that only beta-(1,3)-D-glucan was metabolized by . These cell culture data suggest that beta-(1,3)-D-glucan may not be selectively utilized by healthy commensal bacteria, and its role in intestinal pathogen growth warrants further exploration in vivo.
是一种新兴病原体，可导致严重的食源性疾病——李斯特菌病。共生肠道微生物群是抵御病原体内化的第一道防线。肠道微生物组可被益生元底物改变，益生元底物经常添加到食品和膳食补充剂中。益生元应选择性地支持有益微生物的生长，从而改善宿主健康。然而，人们对它们对……生长的影响知之甚少。本研究的目的是评估代表最常见血清型的四种……菌株在益生元低聚糖（β-(1,3)-D-葡聚糖、菊粉、低聚果糖、低聚半乳糖、乳果糖、棉子糖、水苏糖和2'-岩藻糖基乳糖以及人乳低聚糖混合物）作为唯一碳源时的生长能力。结果表明，只有β-(1,3)-D-葡聚糖被……代谢。这些细胞培养数据表明，健康的共生细菌可能不会选择性地利用β-(1,3)-D-葡聚糖，其在肠道病原体生长中的作用值得在体内进一步探索。
