Ferro Ignacio, Lopez Walter, Cassinelli Flavia, Aguirre Sara, Cuyckens Griet A E, Kehl Sebastián, Abán-Moreyra Daira, Castillo Paola, Bellomo Carla, Gil José, Martinez Valeria P
Andean Ecoregions Institute (Instituto de Ecorregiones Andinas-INECOA), National Scientific and Technical Research Council (CONICET), National University of Jujuy (UNJu), San Salvador de Jujuy 4600, Argentina.
Institute for Tropical Disease Research (Instituto de Investigaciones de Enfermedades Tropicales-IIET), National University of Salta (UNSa), Orán A4530, Argentina.
Pathogens. 2024 Sep 2;13(9):753. doi: 10.3390/pathogens13090753.
Hantavirus pulmonary syndrome (HPS) is an American emerging disease caused by the rodent-borne virus genus (Family: : Order: Class: ). In Argentina, almost half of the HPS infections occur in the northwestern endemic region. In this study, we monitored rodent abundance during 2022 and 2023 in three sites with different sampling methods (removal trapping, live trapping and hunted rodents by domestic cats) to evaluate their relationship with human infections. We found a similar pattern of variation in rodent abundance across time, and particularly a synchronous rise of rodent abundance that anticipated an HPS outbreak in 2023. Our dynamic regression models revealed a positive relationship between HPS cases and rodent abundance with a three-month lag, as well as rainfall with an eight-month lag. Our results provide a framework for the planning and implementation of public health prevention campaigns based on climatology and rodent monitoring. Domestic cats bringing rodents into houses can be an overlooked risk factor, particularly if viral shedding of infected rodents is magnified by stress. HPS is a disease of public health concern due to its high mortality rate, the lack of a specific therapeutic treatment and no vaccine. Thus, prevention of infections is of the utmost importance.
汉坦病毒肺综合征（HPS）是一种由啮齿动物传播的病毒属（科： ；目： ；纲： ）引起的美国新发疾病。在阿根廷，几乎一半的汉坦病毒肺综合征感染发生在西北部的流行地区。在本研究中，我们于2022年和2023年期间，在三个地点采用不同的采样方法（清除诱捕、活体诱捕和家猫捕杀啮齿动物）监测啮齿动物数量，以评估它们与人类感染之间的关系。我们发现，啮齿动物数量随时间变化呈现出相似的模式，特别是在2023年汉坦病毒肺综合征疫情爆发之前，啮齿动物数量同步上升。我们的动态回归模型显示，汉坦病毒肺综合征病例与滞后三个月的啮齿动物数量以及滞后八个月的降雨量之间存在正相关关系。我们的研究结果为基于气候学和啮齿动物监测的公共卫生预防活动的规划和实施提供了一个框架。家猫将啮齿动物带入家中可能是一个被忽视的风险因素，特别是当受感染啮齿动物因应激而病毒脱落增加时。由于汉坦病毒肺综合征死亡率高、缺乏特效治疗方法且无疫苗，它是一个公共卫生关注的疾病。因此，预防感染至关重要。
