Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' an 710032, China.
State Key Laboratory of Component-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, PR China.
J Control Release. 2024 Mar;367:366-384. doi: 10.1016/j.jconrel.2024.01.053. Epub 2024 Feb 1.
Intranasal drug delivery is as a noninvasive and efficient approach extensively utilized for treating the local, central nervous system, and systemic diseases. Despite numerous reviews delving into the application of intranasal drug delivery across biomedical fields, a comprehensive analysis of advancements and future perspectives remains elusive. This review elucidates the research progress of intranasal drug delivery through a scientometric analysis. It scrutinizes several challenges to bolster research in this domain, encompassing a thorough exploration of entry and elimination mechanisms specific to intranasal delivery, the identification of drugs compatible with the nasal cavity, the selection of dosage forms to surmount limited drug-loading capacity and poor solubility, and the identification of diseases amenable to the intranasal delivery strategy. Overall, this review furnishes a perspective aimed at galvanizing future research and development concerning intranasal drug delivery.
鼻腔给药是一种非侵入性且高效的方法，广泛用于治疗局部、中枢神经系统和全身性疾病。尽管有许多综述深入探讨了鼻腔给药在生物医学领域的应用，但对于该领域的进展和未来展望仍缺乏全面的分析。本综述通过科学计量分析阐明了鼻腔给药的研究进展。它仔细研究了增强该领域研究的几个挑战，包括深入探讨鼻腔给药特有的进入和消除机制、确定与鼻腔相容的药物、选择剂型以克服有限的载药量和较差的溶解度，以及确定适合鼻腔给药策略的疾病。总的来说，这篇综述提供了一个视角，旨在激发未来鼻腔给药的研究和开发。
