The Faculty of Science and Technology, Jan Długosz University in Czestochowa, 13/15 Armii Krajowej Av., 42-200 Czestochowa, Poland.
Molecules. 2024 Sep 11;29(18):4301. doi: 10.3390/molecules29184301.
Ampicillin (AMP) and amoxicillin (AMX) are popular antibiotics, which are penicillin derivatives, and are used in both human and veterinary medicine. In the conducted study, AMP, AMX and their mixtures did not cause major changes in the total bacterial counts in soil samples, and even an increase in the bacterial counts from 3,700,000 to 6,260,000 colony-forming units (cfu) per gram of soil dry weight (g of soil DW) was observed for minimal amounts of these drugs in the soil. The total abundance of fungi, on the other hand, increased from values ranging from 17,000 to 148,000 cfu∙g of soil DW to a level of 32,000 to 131,000 cfu∙g of soil DW. The tested antibiotics and their mixtures had no significant effect on the mortality and growth of . AMX and the AMP + AMX mixture also showed no effect on the plant fresh weight yield, plant aboveground part length and dry weight content of wheat seedlings. In contrast, AMP caused an increase in the plant fresh weight yield and wheat seedling length compared to the control. The drug also caused a slight decrease in the seedling dry weight content. Both AMP and AMX showed inhibitory effects on the plant root length at the highest concentrations of the compounds.
氨苄青霉素（AMP）和阿莫西林（AMX）是两种常用的抗生素，属于青霉素衍生物，在人和兽医医学中都有应用。在本研究中，AMP、AMX 及其混合物在土壤样本中的总细菌计数中未引起重大变化，甚至在土壤中这些药物的最小剂量下，观察到细菌计数从 370 万增至 626 万菌落形成单位/克土壤干重（g 土壤 DW）。另一方面，真菌的总丰度从 17,000 至 148,000 个 cfu·g 的土壤 DW 增加到 32,000 至 131,000 个 cfu·g 的土壤 DW。测试的抗生素及其混合物对. 的死亡率和生长没有显著影响。AMX 和 AMP+AMX 混合物也对小麦幼苗的鲜重产量、地上部分长度和干重没有影响。相比之下，AMP 与对照相比，增加了植物鲜重产量和小麦幼苗长度。该药物还导致幼苗干重含量略有下降。在化合物的最高浓度下，AMP 和 AMX 均表现出对植物根长的抑制作用。
