Sabbatini F, Fimmel C J, Pace F, Tobler P H, Hinder R A, Blum A L, Fischer J A
Digestion. 1985;32(4):273-81. doi: 10.1159/000199248.
Intracerebroventricularly (ICV) administered [125I] salmon calcitonin (sCT) was rapidly transported to the blood, but the permeability of the blood-brain barrier to sCT was low. ICV injected intact [125I]sCT was predominantly deposited in the periventricular mesencephalon and in the kidneys, and intravenously (IV) injected [125I]sCT in the kidneys, respectively. After both ICV and IV administration [125I]sCT was not retained by the stomach in large amounts. ICV and subcutaneously (SC) injected sCT caused suppression of gastric secretion volume, and of acid and pepsin outputs; the potency ratios between half maximal inhibitory amounts of sCT administered SC and ICV were 161, 252 and 13, respectively. On the other hand, perfusion of isolated whole mouse stomachs with sCT did not affect basal or stimulated acid and pepsin secretion. These findings indicate that sCT inhibits gastric acid secretion via receptors localized in the hypothalamus and in adjacent areas of the brain.
脑室内（ICV）注射的[125I]鲑鱼降钙素（sCT）能迅速转运至血液中，但血脑屏障对sCT的通透性较低。脑室内注射的完整[125I]sCT主要分别沉积于脑室周围中脑和肾脏，静脉注射（IV）的[125I]sCT则主要沉积于肾脏。脑室内和静脉注射后，[125I]sCT均不会大量滞留于胃内。脑室内和皮下（SC）注射sCT均可抑制胃液分泌量以及胃酸和胃蛋白酶的分泌量；皮下注射和脑室内注射sCT的半数最大抑制量之间的效价比分别为161、252和13。另一方面，用sCT灌注离体的完整小鼠胃，对基础胃酸和胃蛋白酶分泌或刺激后的胃酸和胃蛋白酶分泌均无影响。这些发现表明，sCT通过位于下丘脑及脑内相邻区域的受体抑制胃酸分泌。
