Qu Jing, Sun Yan, Liang Na, Li Cheng, Huang Qian, Wang Mingjie, Wang Deyun, Zhou Bing
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
Department of Otolaryngology, Beijing Huaxin Hospital, First Hospital of Tsinghua University, Beijing, PR China.
Am J Rhinol Allergy. 2025 Jan;39(1):21-31. doi: 10.1177/19458924241282094. Epub 2024 Sep 28.
Sinonasal inverted papilloma (SNIP) is a benign epithelial tumor with distinctive histopathological features. However, the role of inflammation in SNIP remains poorly characterized.
This study aimed to compare the histopathological patterns and inflammatory characteristics of SNIP with those of chronic rhinosinusitis with nasal polyps (CRSwNPs) or normal ethmoid sinus mucosa.
Fifty-eight tissue biopsies were prospectively collected from 38 patients with SNIPs, 12 CRSwNPs, and 8 normal ethmoid sinus mucosae. SNIP was histopathologically divided into four grades based on the extent of epithelial remodeling. The immunohistochemical characteristics of epithelial remodeling (p63, CK5) and infiltration of inflammatory cells (eg, eosinophils, neutrophils, and macrophages) and cytokines (eg, interleukin-1β, interleukin-6, and tumor necrosis factor-α) were analyzed.
Among the 38 SNIPs, 21.1%, 36.8%, 23.7%, and 18.4% were grades I, II, III, and IV, respectively. The expression levels of p63 and CK5 were significantly higher in SNIP than in the other two groups (both, < 0.05). Neutrophil and macrophage infiltration was more pronounced in SNIP and with differences among the four grades. The expression levels of inflammatory cytokines were significantly higher in the SNIP group than in the CRSwNP group. A positive correlation between the expression levels of p63 and inflammatory cytokines was observed in both SNIPs and CRSwNPs.
Excessive epithelial remodeling is an important histological feature of SNIP; it is accompanied by sinonasal mucosal inflammation.
鼻窦内翻性乳头状瘤（SNIP）是一种具有独特组织病理学特征的良性上皮性肿瘤。然而，炎症在SNIP中的作用仍未得到充分描述。
本研究旨在比较SNIP与慢性鼻-鼻窦炎伴鼻息肉（CRSwNPs）或正常筛窦黏膜的组织病理学模式和炎症特征。
前瞻性收集了38例SNIP患者、12例CRSwNPs患者和8例正常筛窦黏膜的58份组织活检标本。根据上皮重塑程度，将SNIP组织病理学分为四级。分析上皮重塑（p63、CK5）、炎性细胞（如嗜酸性粒细胞、中性粒细胞和巨噬细胞）浸润及细胞因子（如白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α）的免疫组化特征。
在38例SNIP中，I级、II级、III级和IV级分别占21.1%、36.8%、23.7%和18.4%。SNIP中p63和CK5的表达水平显著高于其他两组（均P<0.05）。中性粒细胞和巨噬细胞浸润在SNIP中更为明显，且在四个级别之间存在差异。SNIP组炎性细胞因子的表达水平显著高于CRSwNP组。在SNIP和CRSwNP中均观察到p63表达水平与炎性细胞因子之间呈正相关。
过度的上皮重塑是SNIP的重要组织学特征，且伴有鼻窦黏膜炎症。
