单环β-内酰胺类抗生素Ro 17-2301对肠杆菌科细菌及铜绿假单胞菌临床分离株的体外活性

In-vitro activity of the monobactam Ro 17-2301 against clinical isolates of Enterobacteriaceae and Pseudomonas aeruginosa.

作者信息

Bremner D A

出版信息

J Antimicrob Chemother. 1985 Oct;16(4):457-61. doi: 10.1093/jac/16.4.457.

DOI:10.1093/jac/16.4.457

Abstract

Ro 17-2301 is a monobactam antibiotic. Its in-vitro activity was compared with those of aztreonam, ampicillin, cefuroxime, ceftriaxone, ceftazidime, and gentamicin. Ro 17-2301 had qualitatively similar activity to aztreonam and activity superior to that all the other antibiotics against the Enterobacteriaceae, but against Pseudomonas aeruginosa ceftazidime had equal or marginally better activity.

摘要

Ro 17-2301是一种单环β-内酰胺类抗生素。将其体外活性与氨曲南、氨苄西林、头孢呋辛、头孢曲松、头孢他啶和庆大霉素的体外活性进行了比较。Ro 17-2301对肠杆菌科细菌的活性在性质上与氨曲南相似，且优于所有其他抗生素，但对铜绿假单胞菌，头孢他啶的活性与之相当或略强。