斯洛伐克共和国境内感染艾滋病毒的乌克兰战争难民的人口统计学、流行病学和临床特征。
Demographic, epidemiological and clinical characteristics of Ukrainian war refugees with HIV infection in the Slovak Republic.
作者信息
Massmann Ricardo, Doležalová Kristína, Soják Lubomír, Samsonová Olena, Staneková Danica Valkovičová, Zahornacký Ondrej, Jarčuška Pavol, Záriš Vachalíková Mária, Vološinová Diana, Piesecká Ľubica, Vahalová Veronika, Šimeková Katarína, Smiešková Terézia, Bražinová Alexandra, Kigen Ivy, Malý Marek, Machala Ladislav
机构信息
HIV/AIDS Centre, Clinic of Infectious Diseases Akademika Ladislava Dérera, University Hospital Bratislava, Slovakia; Third Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine, Comenius University, Bratislava.
Institute of Epidemiology, Faculty of Medicine, Comenius University in Bratislava, Slovakia.
出版信息
Travel Med Infect Dis. 2024 Nov-Dec;62:102764. doi: 10.1016/j.tmaid.2024.102764. Epub 2024 Sep 27.
BACKGROUND
The Slovak Republic, an Eastern European country, borders Ukraine, which has one of the highest rates of HIV/AIDS in Europe. This study aims to inform readers about the demographic characteristics of Ukrainian war refugees with HIV/AIDS seeking temporary protection status in Slovakia due to the Russian invasion of February 24, 2022. It focuses on their epidemiology, immunological profiles, co-infections, and treatment.
DESIGN
Multicenter, retrospective study between March 1, 2022, and March 31, 2023.
METHODS
Data were collected from all Ukrainian patients with refugee status living with HIV or newly diagnosed, who presented to any of the five HIV/AIDS centers in Slovakia. Information was obtained through medical interviews, physical examinations, laboratory tests and medical reports from the Ukrainian Ministry of Health.
RESULTS
From March 1, 2022, to March 31, 2023, 141 Ukrainian refugees were included, mostly women (56.7 %, n = 80), with a median age of 41 years. The median CD4 count was 680 cells/mL; 69.2 % (n = 97) had a viral load below 40 copies/mL. On arrival, 87.8 % (n = 123) were on ART, 90.2 % (n = 111) on dolutegravir. Coinfections included hepatitis C (31 %, n = 41), hepatitis B (12.5 %, n = 17), and tuberculosis (11.3 %, n = 16). Three died from AIDS complications.
CONCLUSION
The study provides a detailed overview of the epidemiological, demographic, immunological, co-infection, and treatment characteristics of Ukrainian PLWHA displaced by the war to the Slovak republic. With the conflict ongoing, it is necessary to be prepared for more refugees in the coming months.
背景
斯洛伐克共和国是一个东欧国家，与乌克兰接壤，而乌克兰是欧洲艾滋病病毒/艾滋病感染率最高的国家之一。本研究旨在让读者了解因2022年2月24日俄罗斯入侵而在斯洛伐克寻求临时保护身份的携带艾滋病病毒/艾滋病的乌克兰战争难民的人口特征。研究重点关注他们的流行病学、免疫状况、合并感染情况及治疗情况。
设计
2022年3月1日至2023年3月31日期间的多中心回顾性研究。
方法
收集了所有居住在斯洛伐克且具有难民身份的携带艾滋病病毒或新诊断出艾滋病的乌克兰患者的数据，这些患者前往斯洛伐克的五个艾滋病病毒/艾滋病中心中的任何一个就诊。信息通过医学访谈、体格检查、实验室检测以及乌克兰卫生部的医学报告获取。
结果
2022年3月1日至2023年3月31日期间，纳入了141名乌克兰难民，其中大多数为女性（56.7%，n = 80），中位年龄为41岁。CD4细胞计数中位数为680个/毫升；69.2%（n = 97）的病毒载量低于40拷贝/毫升。抵达时，87.8%（n = 123）的患者正在接受抗逆转录病毒治疗，90.2%（n = 111）使用度鲁特韦。合并感染包括丙型肝炎（31%，n = 41）、乙型肝炎（12.5%，n = 17）和结核病（11.3%，n = 16）。三人死于艾滋病相关并发症。
结论
本研究详细概述了因战争流离至斯洛伐克共和国的携带艾滋病病毒的乌克兰人在流行病学、人口统计学、免疫状况、合并感染及治疗方面的特征。随着冲突持续，有必要为未来几个月更多难民的到来做好准备。
Zotero 插件