血清载脂蛋白 B100 联合海马体积对阿尔茨海默病的诊断价值。
Diagnostic Value of Serum Apolipoprotein B100 Combined With Hippocampal Volume in Alzheimer's Disease.
机构信息
Department of Neurology, The Affiliated People's Hospital of, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Department of Radiology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
出版信息
Brain Behav. 2024 Oct;14(10):e70066. doi: 10.1002/brb3.70066.
PURPOSE
To explore the diagnostic value of serum apolipoprotein B100 (Apo B100) combined with hippocampal volume in Alzheimer's disease (AD).
METHODS
A total of 59 AD patients and 59 healthy subjects were selected. The Mini-Mental State Examination (MMSE) was used for neuropsychological assessment. Blood glucose and serum lipid levels were detected by biochemical analyzer. Polymerase chain reaction (PCR) was used to detect apolipoprotein E (Apo E) ε3/ε4 genotypes in the plasma. Hippocampal volume was calculated using Slicer software. Independent-sample t test or Mann-Whitney U test were used to compare the levels of various indicators between the two groups. Spearman's correlation analysis was used to analyze the correlation between each level. The receiver operating characteristic curve (ROC) was plotted, and the area under the curve (AUC) was calculated to compare the diagnostic efficacy of individual and combined detection of serum Apo B100 levels and hippocampal volume in AD.
RESULTS
Compared with the healthy control group, the levels of serum total cholesterol (TC), low-density lipoprotein (LDL), Apo B100, and plasma Apo E ε3/ε4 were higher in the AD group, and serum high-density lipoprotein (HDL) level was lower in the AD group (both p < 0.05). The hippocampal volume in the AD group was lower than in the control group (p < 0.01). The serum Apo B100 level was negatively correlated with MMSE score (r = -0.646), whereas hippocampal volume was positively correlated with MMSE score (r = 0.630). ROC curve analysis showed that the AUC of the combined serum Apo B100 level and hippocampal volume for AD was higher than that of either alone (AUC = 0.821, p < 0.01).
CONCLUSION
Serum Apo B100 level is elevated, and the hippocampal volume is reduced in AD patients. The combined detection of the two has a higher diagnostic efficiency for AD than other alone and has the potential to become an important indicator for the diagnosis of AD in the future.
目的
探讨血清载脂蛋白 B100（Apo B100）联合海马体积对阿尔茨海默病（AD）的诊断价值。
方法
选取 59 例 AD 患者和 59 例健康对照者，采用简易精神状态检查量表（MMSE）进行神经心理学评估，采用生化分析仪检测血糖和血清脂质水平，采用聚合酶链反应（PCR）检测血浆载脂蛋白 E（Apo E）ε3/ε4 基因型，采用 Slicer 软件计算海马体积。采用独立样本 t 检验或 Mann-Whitney U 检验比较两组间各指标水平，采用 Spearman 相关分析分析各水平间的相关性，绘制受试者工作特征曲线（ROC），计算曲线下面积（AUC），比较血清 Apo B100 水平和海马体积单独及联合检测对 AD 的诊断效能。
结果
与健康对照组比较，AD 组血清总胆固醇（TC）、低密度脂蛋白（LDL）、Apo B100 及血浆 Apo E ε3/ε4 水平升高，高密度脂蛋白（HDL）水平降低（均 P<0.05）；AD 组海马体积低于对照组（P<0.01）。血清 Apo B100 水平与 MMSE 评分呈负相关（r=-0.646），海马体积与 MMSE 评分呈正相关（r=0.630）。ROC 曲线分析显示，血清 Apo B100 水平与海马体积联合检测对 AD 的 AUC 高于两者单独检测（AUC=0.821，P<0.01）。
结论
AD 患者血清 Apo B100 水平升高，海马体积减小。两者联合检测对 AD 的诊断效能较其他单项检测更高，有望成为未来 AD 诊断的重要指标。
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