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Challenging the paradigm of alpha-synuclein's role in disease: can low levels also be bad for you?

作者信息

Clemens Stefan, Zeczycki Tonya N

机构信息

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

出版信息

Sleep. 2025 Jan 13;48(1). doi: 10.1093/sleep/zsae229.

DOI:10.1093/sleep/zsae229
PMID:39344682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11725510/
Abstract
摘要

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本文引用的文献

1
Serum alpha-synuclein in restless legs syndrome.不宁腿综合征中的血清α-突触核蛋白
Sleep. 2025 Jan 13;48(1). doi: 10.1093/sleep/zsae217.
2
Detecting α-synuclein seeds in serum to diagnose synucleinopathies.检测血清中的α-突触核蛋白种子以诊断突触核蛋白病。
Nat Med. 2023 Jun;29(6):1328-1329. doi: 10.1038/s41591-023-02402-8.
3
Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection.帕金森病中的α-突触核蛋白：是反派还是悲剧英雄？对多巴胺代谢产物和病毒感染诱导的α-突触核蛋白聚集体形成的批判性观点。
Expert Rev Neurother. 2023 Apr;23(4):321-330. doi: 10.1080/14737175.2023.2196014. Epub 2023 Apr 5.
4
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction.帕金森病和其他突触核蛋白病中的阿尔法-突触核蛋白：从明显的神经退行性变回到早期突触功能障碍。
Cell Death Dis. 2023 Mar 1;14(3):176. doi: 10.1038/s41419-023-05672-9.
5
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles.α-突触核蛋白的生理学与病理学：关于细胞结构和细胞器的观点
Front Neurosci. 2020 Jan 23;13:1399. doi: 10.3389/fnins.2019.01399. eCollection 2019.
6
Interactions between iron and α-synuclein pathology in Parkinson's disease.帕金森病中铁与α-突触核蛋白病理之间的相互作用。
Free Radic Biol Med. 2019 Sep;141:253-260. doi: 10.1016/j.freeradbiomed.2019.06.024. Epub 2019 Jun 22.
7
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.铁调节蛋白 (IRP)-铁反应元件 (IRE) 信号通路在人类神经退行性疾病中的作用。
Mol Neurodegener. 2017 Oct 23;12(1):75. doi: 10.1186/s13024-017-0218-4.
8
Alpha-synuclein levels in blood plasma decline with healthy aging.随着健康衰老，血浆中的α-突触核蛋白水平会下降。
PLoS One. 2015 Apr 6;10(4):e0123444. doi: 10.1371/journal.pone.0123444. eCollection 2015.
9
The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.与帕金森病相关的α-突触核蛋白启动子Rep1等位基因2在不宁腿综合征中的频率降低。
Neurogenetics. 2014 Aug;15(3):189-92. doi: 10.1007/s10048-014-0407-z. Epub 2014 May 27.
10
The many faces of α-synuclein: from structure and toxicity to therapeutic target.α-突触核蛋白的多面性：从结构与毒性到治疗靶点。
Nat Rev Neurosci. 2013 Jan;14(1):38-48. doi: 10.1038/nrn3406.