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Cureus. 2023 Apr 29;15(4):e38316. doi: 10.7759/cureus.38316. eCollection 2023 Apr.
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Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Retrospective Study.人乳头瘤病毒的检测及其与潜在恶性疾病和口腔鳞状细胞癌的关联：一项回顾性研究。
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4
DNA methylation markers for oral pre-cancer progression: A critical review.口腔癌前病变进展的DNA甲基化标志物：批判性综述
Oral Oncol. 2016 Feb;53:1-9. doi: 10.1016/j.oraloncology.2015.11.012. Epub 2015 Dec 12.
5
Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy.唾液冲洗液中内皮素受体 B 基因启动子超甲基化与口腔癌及癌前病变的风险独立相关。
Cancer Prev Res (Phila). 2010 Sep;3(9):1093-103. doi: 10.1158/1940-6207.CAPR-10-0115. Epub 2010 Aug 26.
6
Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression.人端粒酶逆转录酶（hTERT）、死亡相关蛋白激酶（DAPK）和O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）基因启动子高甲基化与宫颈癌发生发展的相关性
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预测口腔癌进展和患者预后的遗传标志物研究。

Investigation of Genetic Markers for Predicting Oral Cancer Progression and Patient Outcomes.

作者信息

Wasti Amit, Mohanty Liza, Shukla Ruchira, Gupta Bharti, Gowdar Inderjit Murugendrappa, Mehta Tarang, Makkad Ramanpal Singh

机构信息

Department of Oral Pathology and Microbiology, Government Dental College, Raipur, Chhattisgarh, India.

Department of Dentistry, Government Medical College and Hospital, Sundargarh, Odisha, India.

出版信息

J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2129-S2131. doi: 10.4103/jpbs.jpbs_113_24. Epub 2024 May 1.

DOI:10.4103/jpbs.jpbs_113_24
PMID:39346291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426564/
Abstract

BACKGROUND

Genomic methylation being used as a sensitive indicator for identifying oral potentially malignant disorders (OPMDS) and oral cancer could be a viable option. DNA methylation is a potential approach for "cancer therapeutics" and can help researchers truly understand the genomic mechanism that leads to cancer.

AIM

Investigation of genetic markers for predicting oral cancer progression and patient outcomes.

METHODS AND MATERIALS

One hundred and twelve patients having oral premalignant lesions and malignant lesions were included in this study. Saliva samples were obtained for analysis of the expression of genetic markers, such as p16, DAP-K, and MGMT. The Illumina Infinium HumanMethylation450 BeadChip (Illumina Inc., USA) would be used to assess genome-wide DNA methylation according to the manufacturer's instructions.

RESULTS

Methylation of all the genes, that is, p16, DAP-K, and MGMT, was observed in 12.7% of oral cancer lesions. 41.94% of oral cancer lesions were found to have methylation of two genes. 13.23% cases were found to be associated with methylation of p16 and DAP-K, 12.12% cases were found to have methylation in the p16 and MGMT, and 15.27% cases of oral cancer lesions showed methylation of DAP-K and MGMT.

CONCLUSION

Genetic markers, such as p53, DAP-K, and MGMT, can be used for predicting oral cancer progression and patient outcomes.

摘要

背景

基因组甲基化作为识别口腔潜在恶性疾病（OPMDS）和口腔癌的敏感指标可能是一种可行的选择。DNA甲基化是“癌症治疗学”的一种潜在方法，有助于研究人员真正理解导致癌症的基因组机制。

目的

研究预测口腔癌进展和患者预后的遗传标志物。

方法和材料

本研究纳入了112例患有口腔癌前病变和恶性病变的患者。采集唾液样本用于分析p16、DAP-K和MGMT等遗传标志物的表达。将根据制造商的说明使用Illumina Infinium HumanMethylation450 BeadChip（美国Illumina公司）评估全基因组DNA甲基化。

结果

在12.7%的口腔癌病变中观察到所有基因（即p16、DAP-K和MGMT）的甲基化。41.94%的口腔癌病变被发现有两个基因的甲基化。发现13.23%的病例与p16和DAP-K的甲基化有关，12.12%的病例在p16和MGMT中有甲基化，15.27%的口腔癌病变显示DAP-K和MGMT的甲基化。

结论

p53、DAP-K和MGMT等遗传标志物可用于预测口腔癌进展和患者预后。