Singh Anju, Sharma Ankita, Srivastava Shivi, Jaiswal Akarshi, Mere Kekhrieneinuo, Dixit Heena, Mahobia Ashish
Department of Ophthalmology, ASMC, Etah, Uttar Pradesh, India.
Department of Pathology, Veerangana Avantibai Lodhi, Autonomous State Medical College, Etah, Uttar Pradesh, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2624-S2627. doi: 10.4103/jpbs.jpbs_410_24. Epub 2024 Jul 1.
Ocular surface squamous neoplasia (OSSN) encompasses a range of dysplastic changes from mild dysplasia to invasive carcinoma. This research aims to elucidate the cytomorphological spectrum of OSSN in the elderly age group and correlate these findings with clinical and pathological features.
A retrospective analysis was conducted on elderly patients (>60 years) diagnosed with OSSN over a 5 year period. Cytological and histopathological findings were analyzed and correlated with clinical data.
The cytomorphological spectrum of OSSN in the elderly age group exhibited a broad range of cellular changes, from mild dysplasia to invasive squamous cell carcinoma. The predominant cytological features included increased nuclear-cytoplasmic ratio, pleomorphism, and abnormal mitotic figures. Clinically, OSSN presented most commonly as a unilateral conjunctival mass with a history of chronic irritation. Histopathologically, there was a significant correlation between the degree of dysplasia and the depth of invasion ( < 0.05).
This research highlights the diverse cytomorphological spectrum of OSSN in the elderly age groups and emphasizes the importance of comprehensive clinicopathological correlation for accurate diagnosis and management. The predominant cytological features observed, including increased nuclear-cytoplasmic ratio, pleomorphism, and abnormal mitotic figures, reflect the underlying dysplastic alterations and provide valuable insights into the diagnosis and the classification of OSSN. Further studies are warranted to explore the potential role of impression cytology in the diagnosis and management of OSSN and to evaluate the efficacy of different treatment modalities in the elderly age group.
眼表鳞状上皮肿瘤（OSSN）涵盖了从轻度发育异常到浸润性癌的一系列发育异常变化。本研究旨在阐明老年年龄组中OSSN的细胞形态学谱，并将这些发现与临床和病理特征相关联。
对5年内诊断为OSSN的老年患者（>60岁）进行回顾性分析。分析细胞学和组织病理学发现，并与临床数据相关联。
老年年龄组中OSSN的细胞形态学谱呈现出广泛的细胞变化，从轻度发育异常到浸润性鳞状细胞癌。主要的细胞学特征包括核质比增加、多形性和异常有丝分裂象。临床上，OSSN最常见的表现为单侧结膜肿物，伴有慢性刺激史。组织病理学上，发育异常程度与浸润深度之间存在显著相关性（<0.05）。
本研究突出了老年年龄组中OSSN多样的细胞形态学谱，并强调了综合临床病理相关性对于准确诊断和管理的重要性。观察到的主要细胞学特征，包括核质比增加、多形性和异常有丝分裂象，反映了潜在的发育异常改变，并为OSSN的诊断和分类提供了有价值的见解。有必要进一步研究以探索印片细胞学在OSSN诊断和管理中的潜在作用，并评估老年年龄组中不同治疗方式的疗效。
