Mahobia Ashish, Sahoo Sujit Ranjan, Maiti Niladri, Sathyanarayanan R, Aravinth R, Pandraveti Roopa Reddy, Tiwari Heena
Department of Ophthalmology, SBH Eye Hospital, Raipur, Chhattisgarh, India.
Department of Dentistry, PRM Medical College and Hospital, Baripada, Odisha, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1365-S1368. doi: 10.4103/jpbs.jpbs_199_21. Epub 2021 Nov 10.
Diabetes is associated with the vascular and the neuronal damage of the eye leading to diabetic retinopathy (DR). The circadian rhythms and also the quality of life (QoL) are known to be impacted by the photosensitive retinal ganglion cells, which are seen to be affected in the DR. Hence, we aim to find a relation between the DR and its impact on the life quality.
Thousand participants were equally divided into two groups of case and controls (DR). The control group was further divided into three subgroups based on the severity of the disease as proliferative and nonproliferative (mild, moderate, and severe). The impact on the QoL was assessed using the Short Form Health Survey-36. The collected data were analyzed for the various grades of the severity of DR on the quality of the life.
There was a notable change between the case and the controls and the QoL deteriorated with the severity of the disease. However, these findings were insignificant statistically.
DR impacts the QoL of the patients, and the severity of the disease is proportional to the worsening of the disease. Further, research is warranted for the association.
糖尿病与眼部血管及神经损伤相关，可导致糖尿病视网膜病变（DR）。已知昼夜节律以及生活质量（QoL）会受到光敏感视网膜神经节细胞的影响，而这些细胞在糖尿病视网膜病变中会受到影响。因此，我们旨在找出糖尿病视网膜病变与其对生活质量的影响之间的关系。
将一千名参与者平均分为病例组和对照组（糖尿病视网膜病变组）。对照组根据疾病严重程度进一步分为三个亚组，即增殖性和非增殖性（轻度、中度和重度）。使用简短健康调查问卷-36评估对生活质量的影响。对收集的数据进行分析，以研究糖尿病视网膜病变不同严重程度等级对生活质量的影响。
病例组与对照组之间存在显著差异，生活质量随疾病严重程度恶化。然而，这些发现无统计学意义。
糖尿病视网膜病变会影响患者的生活质量，疾病严重程度与病情恶化程度成正比。此外，有必要对这种关联进行进一步研究。
