Kumar Pvsn Kiran, Japa Pradeep, Tomo Sojit, Sankanagoudar Shrimanjunath, Purohit Purvi, Charan Jayakaran, Purohit Abhishek, Nag Vijaya Lakshmi, Bhatia Pradeep Kumar, Singh Kuldeep, Dutt Naveen, Garg Mahendra Kumar, Misra Sanjeev, Sharma Praveen, Yadav Dharamveer
Department of Biochemistry, Andhra Medical College, Visakhapatnam, India.
Department of Biochemistry, All India Institute of Medical Sciences, Basni, Jodhpur, Rajasthan 342005 India.
Indian J Clin Biochem. 2024 Oct;39(4):548-556. doi: 10.1007/s12291-024-01225-9. Epub 2024 Apr 21.
The COVID-19 pandemic has underscored the critical importance of understanding the intricate relationship between micronutrient levels and disease outcomes. This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality. The study involves 200 participants (100 COVID-19 patients, 100 controls), we meticulously analyzed micronutrient dynamics. Calcium, phosphorus, magnesium and ALP was measured spectrophotometrically. Vitamin D was measured using Chemiluminescent method. The study reveals that diminished levels of calcium, phosphorus, magnesium, and with elevated ALP, are significantly associated with COVID-19 cases. Whereas the Vitamin D levels in severe group was increased when compared to mild cases but decreased than control group. Disease severity correlated with declining calcium (r = - 0.35, < 0.01), phosphorus (r = - 0.26, < 0.05), and magnesium (r = - 0.21, < 0.05), and increased ALP (r = 0.42, < 0.001). Post-discharge, calcium ( < 0.05) and phosphorus ( < 0.01) showed positive trends, while ALP ( < 0.001) decreased. Notably, calcium (OR = 0.63, < 0.05) and ALP (OR = 1.87, < 0.001) emerged as significant predictors of disease severity. The findings not only illuminate potential therapeutic avenues but also emphasize the need to optimize nutrient levels, including magnesium, for COVID-19 prevention and management. Given the complexities of these relationships, further rigorous exploration, including well-designed trials and understanding underlying mechanisms, is imperative to unravel the dynamics of these nutrient interactions in the context of COVID-19.
The online version contains supplementary material available at 10.1007/s12291-024-01225-9.
新冠疫情凸显了理解微量营养素水平与疾病结局之间复杂关系的至关重要性。本研究探讨了维生素D、钙、磷、镁和碱性磷酸酶（ALP）对新冠严重程度和死亡率的影响。该研究涉及200名参与者（100名新冠患者，100名对照），我们精心分析了微量营养素动态变化。采用分光光度法测定钙、磷、镁和ALP。使用化学发光法测定维生素D。研究表明，钙、磷、镁水平降低以及ALP升高与新冠病例显著相关。而重症组的维生素D水平与轻症病例相比有所升高，但与对照组相比有所降低。疾病严重程度与钙（r = -0.35，<0.01）、磷（r = -0.26，<0.05）和镁（r = -0.21，<0.05）水平下降以及ALP升高（r = 0.42，<0.001）相关。出院后，钙（<0.05）和磷（<0.01）呈上升趋势，而ALP（<0.001）下降。值得注意的是，钙（OR = 0.63，<0.05）和ALP（OR = 1.87，<0.001）是疾病严重程度的重要预测指标。这些发现不仅揭示了潜在的治疗途径，还强调了优化包括镁在内的营养素水平对于新冠预防和管理的必要性。鉴于这些关系的复杂性，进行进一步严格探索，包括精心设计的试验和理解潜在机制，对于在新冠背景下阐明这些营养素相互作用的动态变化至关重要。
在线版本包含可在10.1007/s12291-024-01225-9获取的补充材料。
