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作为伤口敷料的电纺载香芹酚聚丙烯腈/聚环氧乙烷纳米纤维膜

Electrospun Carvacrol-Loaded Polyacrylonitrile/Poly(ethylene oxide) Nanofibrous Films as Wound Dressings.

作者信息

Wang Shuo, Xu Xinyuan, Zhu Xiangyu, Tan Xiao, Xie Bei

机构信息

Puai Medical School, Shaoyang University, Shaoyang 422000, China.

Diagnostic Molecular Laboratory, Shaoyang University, Shaoyang 422000, China.

出版信息

ACS Omega. 2024 Sep 13;9(38):39472-39483. doi: 10.1021/acsomega.4c03140. eCollection 2024 Sep 24.

DOI:10.1021/acsomega.4c03140
PMID:39346841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11425651/
Abstract

Preventing microbial infections and accelerating wound closure are essential in the process of wound healing. In this study, various concentrations of carvacrol (CA) were loaded into polyacrylonitrile/poly(ethylene oxide) (PAN/PEO) nanofiber membranes to develop potential wound dressing materials via an electrospinning technique. The morphology and structure of the PAN/PEO/CA nanofiber membrane were analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), respectively. Subsequently, antimicrobial performance testing showed that the PAN/PEO/CA nanofiber membrane exhibited antimicrobial activity in a concentration-dependent manner. Moreover, SEM and transmission electron microscopy revealed that the number of decreased significantly and the microstructure of the biofilm was seriously damaged. Next, compared with the control and PAN/PEO groups, the PAN/PEO/5% CA group in a full-thickness skin infection model not only exhibited reduced wound exudate on day 2 after infection but also displayed a greater ability to achieve complete skin regeneration, with faster wound healing. Finally, the Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that the downregulated differentially expressed genes between PAN/PEO- and PAN/PEO/5% CA-treated were enriched in the two-component system and infection. In conclusion, the antimicrobial materials of PAN/PEO/CA inhibited microbial growth and promoted wound healing with potential applications in the clinical management of wounds.

摘要

预防微生物感染和加速伤口闭合在伤口愈合过程中至关重要。在本研究中，通过静电纺丝技术将不同浓度的香芹酚（CA）负载到聚丙烯腈/聚环氧乙烷（PAN/PEO）纳米纤维膜中，以开发潜在的伤口敷料材料。分别通过扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）分析PAN/PEO/CA纳米纤维膜的形态和结构。随后，抗菌性能测试表明，PAN/PEO/CA纳米纤维膜呈现出浓度依赖性抗菌活性。此外，SEM和透射电子显微镜显示生物膜的数量显著减少且其微观结构受到严重破坏。接下来，在全层皮肤感染模型中，与对照组和PAN/PEO组相比，PAN/PEO/5%CA组不仅在感染后第2天伤口渗出物减少，而且在实现完全皮肤再生方面表现出更强的能力，伤口愈合更快。最后，京都基因与基因组百科全书通路分析表明，PAN/PEO处理组和PAN/PEO/5%CA处理组之间下调的差异表达基因在双组分系统和感染方面富集。总之，PAN/PEO/CA抗菌材料抑制微生物生长并促进伤口愈合，在伤口临床管理中具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd72/11425651/94f474c4a7c5/ao4c03140_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd72/11425651/94f474c4a7c5/ao4c03140_0009.jpg

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