用于人类视网膜微观结构和功能成像的超高速多模态自适应光学系统。
Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.
作者信息
Liu Zhuolin, Zhang Furu, Zucca Kelvy, Agrawal Anant, Hammer Daniel X
机构信息
Center for Devices and Radiological Health (CDRH), U. S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, USA.
Co-first author.
出版信息
Biomed Opt Express. 2022 Oct 17;13(11):5860-5878. doi: 10.1364/BOE.462594. eCollection 2022 Nov 1.
Abstract
We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.
摘要
我们描述了一种多模态多功能自适应光学（AO）系统的设计与性能，该系统结合了扫描激光检眼镜（SLO）和光学相干断层扫描（OCT），可在13.4Hz下同时进行视网膜成像。高速AO-OCT通道使用3.4MHz傅里叶域锁模（FDML）扫频光源。该系统在对视网膜细胞和结构进行全黄斑和跨视网膜可视化时，实现了极高的分辨率和灵敏度，同时还能对锥状光感受器进行功能评估。超高速还实现了用于临床实用性的宽视野扫描以及用于血管可视化的血管造影。FDA FDML-AO系统是一个强大的平台，可用于视觉科学研究、视网膜生理学研究和生物标志物开发等各种视网膜和神经疾病的研究。
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