Department of Pediatrics, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Department of Neonatal, Shenzhen Longhua District Central Hospital, Shenzhen, China.
PLoS One. 2024 Sep 30;19(9):e0310647. doi: 10.1371/journal.pone.0310647. eCollection 2024.
Previous studies have yielded conflicting results regarding the link between maternal perinatal depression and asthma in children. To provide a clearer understanding of this relationship, a comprehensive meta-analysis was carried out to evaluate the association mentioned above.
A comprehensive review of observational studies was conducted by searching electronic databases including Medline, Embase, and Web of Science. The data were combined using a randomized-effects model taking into account potential variations. Subgroup analyses were performed to evaluate the possible impact of study characteristics on outcomes.
Ten cohort studies, which included 833,230 mother-child pairs, were examined in the analysis. Maternal depressive symptoms during the perinatal period were associated with an increased risk of asthma in offspring (risk ratio [RR]: 1.24, 95% confidence interval [CI]: 1.19 to 1.30, p < 0.001; I2 = 0%). Further sensitivity analyses restricted to multivariate studies (RR: 1.24, 95% CI: 1.19 to 1.30, p < 0.001; I2 = 0%) or studies where asthma was diagnosed in children aged three years or older (RR: 1.24, 95% CI: 1.19 to 1.30, p < 0.001; I2 = 0%) revealed consistent outcomes. Subgroup analyses according to study design, methods for the diagnosis of maternal depression, timing for the evaluation of maternal depression, methods for the validation of asthma in offspring, adjustment of maternal smoking during pregnancy and of maternal asthma, or study quality score showed similar results (p for subgroup difference all > 0.05).
Maternal perinatal depression appears to be significantly linked to a higher occurrence of childhood asthma in children.
先前的研究对于围产期抑郁与儿童哮喘之间的关联得出了相互矛盾的结果。为了更清楚地了解这种关系，进行了一项综合荟萃分析，以评估上述关联。
通过检索 Medline、Embase 和 Web of Science 等电子数据库，对观察性研究进行了全面综述。采用随机效应模型合并数据，考虑了潜在的变异性。进行了亚组分析，以评估研究特征对结果的可能影响。
在分析中检查了 10 项队列研究，共涉及 833230 对母婴对。围产期期间母亲的抑郁症状与后代患哮喘的风险增加相关（风险比 [RR]：1.24，95%置信区间 [CI]：1.19 至 1.30，p < 0.001；I2 = 0%）。进一步的敏感性分析仅限于多变量研究（RR：1.24，95% CI：1.19 至 1.30，p < 0.001；I2 = 0%）或在三岁或以上儿童中诊断出哮喘的研究（RR：1.24，95% CI：1.19 至 1.30，p < 0.001；I2 = 0%）得出了一致的结果。根据研究设计、母亲抑郁诊断方法、母亲抑郁评估时间、后代哮喘验证方法、母亲怀孕期间吸烟和母亲哮喘的调整情况或研究质量评分进行的亚组分析显示出相似的结果（p 对于亚组差异均> 0.05）。
围产期抑郁似乎与儿童哮喘的发生显著相关。
