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儿童急性哮喘管理。

Management of Acute Asthma in Children.

机构信息

West Midlands Deanery, Health Education England (West Midlands), Health Education England, West Midlands, Birmingham, UK.

Division of Pediatric Pulmonology and Sleep, Department of Pediatrics, KTPNUCMI, National University Hospital, Singapore, 119228, Singapore.

出版信息

Indian J Pediatr. 2022 Apr;89(4):366-372. doi: 10.1007/s12098-021-04051-6. Epub 2022 Feb 11.

DOI:10.1007/s12098-021-04051-6
PMID:35147928
Abstract

Asthma is the most common disease of childhood globally and acute asthma is the most significant risk factor for asthma-related death and chronic complications. This article will aim to synthesize the most up-to-date research and translate it into a more practical guide to managing acute asthma on a more daily basis. The use of clinical severity score is reviewed alongside the use of history and clinical findings in making objective assessments of patients presenting with acute asthma. Practical evidence-based pathways and a stepwise approach are provided for management of acute asthma in the home, outpatient, emergency, and intensive care settings. In doing so, popular myths are dispelled and practices in relation to management of acute asthma and use of asthma related medications are clarified. Having a standardized approach to management of acute asthma will bring us one step closer to reducing exacerbations and achieving the goal of having zero tolerance towards exacerbations.

摘要

哮喘是全球最常见的儿童疾病,急性哮喘是哮喘相关死亡和慢性并发症的最重要危险因素。本文旨在综合最新的研究,并将其转化为更实用的指南,以便更日常地管理急性哮喘。本文回顾了临床严重程度评分的使用,以及在对急性哮喘发作患者进行客观评估时,病史和临床发现的使用。提供了家庭、门诊、急诊和重症监护环境中急性哮喘管理的循证实用途径和逐步方法。通过这样做,消除了流行的误解,并澄清了与急性哮喘管理和使用哮喘相关药物有关的做法。对急性哮喘管理采用标准化方法,将使我们离减少加重和实现零容忍加重的目标更近一步。

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本文引用的文献

1
Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children.联合吸入抗胆碱能药物与短效β2受体激动剂用于儿童急性哮喘的初始治疗。
Paediatr Respir Rev. 2013 Dec;14(4):234-5. doi: 10.1016/j.prrv.2013.08.002. Epub 2013 Sep 24.
因严重哮喘急性发作入住儿科重症监护病房的患者哮喘病程评估
Medicina (Kaunas). 2025 Feb 14;61(2):341. doi: 10.3390/medicina61020341.
4
Nitric oxide synthase inhibitors reduce the formation of neutrophil extracellular traps and alleviate airway inflammation in the mice model of asthma.一氧化氮合酶抑制剂可减少中性粒细胞胞外诱捕网的形成,并减轻哮喘小鼠模型中的气道炎症。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 29. doi: 10.1007/s00210-025-03831-7.
5
TRIM7 knockdown protects against LPS-induced autophagy, ferroptosis, and inflammatory responses in human bronchial epithelial cells.TRIM7基因敲低可保护人支气管上皮细胞免受脂多糖诱导的自噬、铁死亡和炎症反应。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):4265-4277. doi: 10.1007/s00210-024-03546-1. Epub 2024 Oct 24.
6
Perinatal maternal depression and the risk of childhood asthma in offspring: A meta-analysis.围产期产妇抑郁与后代儿童哮喘风险:一项荟萃分析。
PLoS One. 2024 Sep 30;19(9):e0310647. doi: 10.1371/journal.pone.0310647. eCollection 2024.
7
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment.呼吸系统疾病与肠道微生物群:相关性、发病机制及治疗
Front Microbiol. 2024 Jul 16;15:1358597. doi: 10.3389/fmicb.2024.1358597. eCollection 2024.
8
Linkage of serum ITIH4 with Th2 signature cytokine, inflammation, exacerbation risk and severity in childhood asthma.血清 ITIH4 与 Th2 特征细胞因子、炎症、儿童哮喘恶化风险和严重程度的关联。
Biomark Med. 2024;18(13-14):593-602. doi: 10.1080/17520363.2024.2366149. Epub 2024 Jul 16.
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The association between waist circumference and adult asthma attack using nationally representative samples.利用全国代表性样本研究腰围与成人哮喘发作之间的关系。
BMC Public Health. 2024 Apr 25;24(1):1158. doi: 10.1186/s12889-024-18656-x.
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How Intuitive Is the Administration of Pediatric Emergency Medication Devices for Parents? Objective Observation and Subjective Self-Assessment.家长对儿科急救用药设备的操作有多直观?客观观察与主观自我评估。
Pharmacy (Basel). 2024 Feb 18;12(1):36. doi: 10.3390/pharmacy12010036.