探索染色体外环状DNA在人类疾病中的作用。
Exploring the Role of Extrachromosomal Circular DNA in Human Diseases.
作者信息
Peng Yali, Tao Huihui, Wang Guoying, Wu Mengyao, Xu Tinatin, Wen Chunmei, Zheng Xuejia, Dai Yong
机构信息
School of Medicine, Anhui University of Science and Technology, Huainan, China.
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China.
出版信息
Cytogenet Genome Res. 2024;164(5-6):181-193. doi: 10.1159/000541563. Epub 2024 Sep 30.
BACKGROUND
Extrachromosomal circular DNA (eccDNA) has emerged as a central focus in molecular biology, with various types being found across species through advanced techniques, including high-throughput sequencing. This dynamic molecule exerts a significant influence on aging and immune function and plays pivotal roles in autoimmune diseases, type 2 diabetes mellitus, cancer, and genetic disorders.
SUMMARY
This comprehensive review investigates the classification, characteristics, formation processes, and multifaceted functions of eccDNA, providing an in-depth exploration of its mechanisms in diverse diseases.
KEY MESSAGES
The goal of this review was to establish a robust theoretical foundation for a more comprehensive understanding of eccDNA, offering valuable insights for the development of clinical diagnostics and innovative therapeutic strategies in the context of related diseases.
背景
染色体外环状DNA（eccDNA）已成为分子生物学的核心研究焦点，通过包括高通量测序在内的先进技术，在跨物种中发现了多种类型。这种动态分子对衰老和免疫功能有重大影响，并在自身免疫性疾病、2型糖尿病、癌症和遗传疾病中发挥关键作用。
总结
本全面综述研究了eccDNA的分类、特征、形成过程和多方面功能，深入探讨了其在多种疾病中的机制。
关键信息
本综述的目的是为更全面地理解eccDNA建立坚实的理论基础，为相关疾病的临床诊断发展和创新治疗策略提供有价值的见解。
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