Ruzal' G I, Galeeva O P, Gazizova G R
Zh Mikrobiol Epidemiol Immunobiol. 1985 Sep(9):46-9.
The present work shows that the cytopathogenic action of N. meningitidis on continuous human amniotic epithelial cell culture FL begins from their active adhesion and subsequent invasion. The degree of the manifestation of the cytopathic effect depends on the capacity of the infective agent for adhesion and invasion and on its biological properties, as well as on the initial state of the cells. The infection of the cells is accompanied by disturbances in their mitotic activity together with the lesions of their chromosomal apparatus. The cells die either in the state of degenerative mitosis, or as the result of the rupture of the cytoplasm in massively invaded cells. The response of the cells to the invasion of faintly cytopathogenic and noncytopathogenic strains takes the form of nonprofessional phagocytosis.
目前的研究表明，脑膜炎奈瑟菌对人羊膜上皮细胞连续培养物FL的细胞致病作用始于其主动黏附及随后的侵袭。细胞病变效应的表现程度取决于感染因子的黏附与侵袭能力及其生物学特性，以及细胞的初始状态。细胞感染伴随着有丝分裂活性的紊乱以及染色体装置的损伤。细胞要么在退行性有丝分裂状态下死亡，要么在大量被侵袭细胞中因细胞质破裂而死亡。细胞对轻度致细胞病变和非致细胞病变菌株侵袭的反应表现为非专职吞噬作用。
