[不同脑膜炎球菌菌株的毒性和毒力]

[Toxicity and virulence of different strains of meningococcus].

作者信息

Kasatskaia L K

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1975 Jun(6):85-9.

Abstract

With the aid of a modified Dubos and Schaedleder's method a determination was made on albino mice of the toxicity of 49 strains of meningococcus. The greatest toxicity was possessed by strains isolated from the cerebrospinal fluid of patients with cerebrospinal meningitis; standard strains were less toxic and strains isolated from healthy carriers were nontoxic. The living and the heated cultures of meningococci produced the same toxic action which was apparently associated with the thermostable antigens of the cell. The virulence studied in 24 strains of meningococcus on a model of 9-day chick embryos failed to correlate with the toxic properties of the strains.

摘要

借助改良的杜波斯（Dubos）和沙德勒德（Schaedleder）方法，对49株脑膜炎球菌对白化小鼠的毒性进行了测定。从脑脊髓膜炎患者脑脊液中分离出的菌株毒性最强；标准菌株毒性较小，而从健康带菌者中分离出的菌株则无毒。脑膜炎球菌的活菌培养物和加热培养物产生相同的毒性作用，这显然与细胞的耐热抗原有关。在9日龄鸡胚模型上对24株脑膜炎球菌进行的毒力研究结果与这些菌株的毒性特性不相关。