Zibanejad Nazanin, Nouri Nikta, Babaie Sharareh
Department of Pediatric Intensive Care Unit, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.
Int J Emerg Med. 2024 Sep 30;17(1):129. doi: 10.1186/s12245-024-00718-x.
Tranexamic acid (TXA) is commonly considered a safe drug to mitigate bleeding during and after various surgical settings among adults and children. In recent decades, anaphylaxis induced by TXA has been increasingly reported in adults. However, among pediatrics, there are fewer reported cases.
We report a case of a 6-year-old female who experienced anaphylaxis after receiving intravenous TXA following unilateral cleft lip and palate repair surgery. She exhibited clinical symptoms involving the cardiovascular system, respiratory system, and skin. Following the administration of epinephrine, corticosteroid, and anti-histamine, the patient's symptoms were relieved. A few months after discharge, an intradermal test, yielded a positive result, confirming TXA as the culprit drug.
Our report emphasizes the importance of considering anaphylaxis as a potential adverse reaction to TXA in pediatric patients, showing the criticality of rapid diagnosis and appropriate management for a successful outcome.
氨甲环酸（TXA）通常被认为是一种安全的药物，可减轻成人和儿童各种手术过程中和术后的出血情况。近几十年来，成人中由TXA引起的过敏反应报告越来越多。然而，儿科病例报告较少。
我们报告一例6岁女性，在单侧唇腭裂修复手术后接受静脉注射TXA后发生过敏反应。她出现了涉及心血管系统、呼吸系统和皮肤的临床症状。在给予肾上腺素、皮质类固醇和抗组胺药后，患者症状缓解。出院几个月后，皮内试验结果呈阳性，证实TXA为致病药物。
我们的报告强调了将过敏反应视为儿科患者TXA潜在不良反应的重要性，显示了快速诊断和适当处理对于成功治疗的关键性。
