Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition research center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Gastroenterol. 2024 Sep 30;24(1):328. doi: 10.1186/s12876-024-03392-8.
Plant foods are naturally rich in anti-inflammatory nutrients. In this cross-sectional study, we assessed the association between the plant-based dietary index (PDI) and Mayo score in patients with ulcerative colitis (UC).
This analytical cross-sectional study included 158 patients with UC. The Mayo score was used to determine disease severity. An expert nutritionist performed the anthropometric assessments. A 168-item quantitative food frequency questionnaire (FFQ) was used to calculate the PDI, healthy PDI (hPDI), and unhealthy PDI (uPDI). To assess the association between the total Mayo score (as a dependent factor) and different indices of PDI (as an independent variable), the linear regression model was used.
The mean age of participants was 42.52 ± 12.61 years. There were significant differences in the total Mayo score between tertiles of PDI score (p = 0.02). The result of linear regression showed that in the unadjusted model, compared with the patients in the first tertile of PDI, the patients in the second (-0.21 (-1.89, -0.17)), and third tertile (-0.21 (-1.95, -0.16)) had significantly lower total mayo scores. The inverse association remained significant after adjusting for covariates. However, uPDI and hPDI tertiles were not significantly associated with total Mayo scores in the adjusted and unadjusted models.
higher PDI was significantly associated with higher UC severity. However, considering the limitations of the study, more cohort studies are needed to confirm these results.
植物性食物天然富含抗炎营养素。在这项横断面研究中，我们评估了植物性饮食指数（PDI）与溃疡性结肠炎（UC）患者梅奥评分之间的关系。
本分析性横断面研究纳入了 158 例 UC 患者。梅奥评分用于确定疾病严重程度。一位专家营养师进行了人体测量评估。采用 168 项定量食物频率问卷（FFQ）计算 PDI、健康 PDI（hPDI）和不健康 PDI（uPDI）。为了评估总 Mayo 评分（作为因变量）与 PDI 不同指数（作为自变量）之间的关系，使用线性回归模型。
参与者的平均年龄为 42.52±12.61 岁。PDI 评分三分位数之间的总 Mayo 评分存在显著差异（p=0.02）。线性回归结果显示，在未调整模型中，与 PDI 评分第一三分位的患者相比，第二（-0.21[-1.89，-0.17]）和第三三分位（-0.21[-1.95，-0.16]）的患者总 Mayo 评分明显较低。调整协变量后，这种关联仍然显著。然而，uPDI 和 hPDI 三分位数与调整和未调整模型中的总 Mayo 评分均无显著相关性。
较高的 PDI 与 UC 严重程度显著相关。然而，考虑到研究的局限性，需要更多的队列研究来证实这些结果。
