Lin Fengyu, Luo Jiefeng, Zhu Yiqun, Liang Huaying, Li Dianwu, Han Duoduo, Chang Qinyu, Pan Pinhua, Zhang Yan
Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Innov Aging. 2024 Aug 10;8(9):igae070. doi: 10.1093/geroni/igae070. eCollection 2024.
Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent.
We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank. The early life factors (eg, maternal smoking, breastfeeding, birth weight, and comparative body size and height to peers at age 10) were measured. The regression coefficients (β) and 95% confidence interval (CI) were applied to assess the link of the early life factors and TL in adulthood. Flexible parametric survival models incorporated age to calculate the relationship between early life factors and life expectancy.
Exposure to maternal smoking, lack of breastfeeding, low birth weight, and shorter height compared to peers at age 10 were identified to be associated with shorter TL in middle and older age according to the large population-based study with 197 504 participants. Individuals who experienced more than 3 adverse early life factors had the shortest TL in middle and late life (β = -0.053; 95% CI = -0.069 to -0.038; < .0001), as well as an average of 0.54 years of life loss at the age of 45 and 0.49 years of life loss at the age of 60, compared to those who were not exposed to any early life risk factors.
Early life factors including maternal smoking, non-breastfed, low birth weight, and shorter height compared to peers at age 10 were associated with shorter TL in later life. In addition, an increased number of the aforementioned factors was associated with a greater likelihood of shorter TL in adulthood, as well as a reduced life expectancy.
端粒长度（TL）已被公认为生物衰老的生物标志物。众多研究探讨了个体早期生活因素与白细胞端粒长度之间的关联；然而，研究结果远未达成一致。
我们利用英国生物银行的数据，评估了个体及综合早期生活因素与中老年白细胞端粒长度之间的关系。测量了早期生活因素（如母亲吸烟、母乳喂养、出生体重以及10岁时与同龄人相比的体型和身高）。应用回归系数（β）和95%置信区间（CI）来评估早期生活因素与成年后端粒长度的联系。灵活的参数生存模型纳入年龄以计算早期生活因素与预期寿命之间的关系。
根据这项有197504名参与者的大型基于人群的研究，母亲吸烟、缺乏母乳喂养、低出生体重以及10岁时比同龄人身高更矮，被确定与中老年端粒长度较短有关。与未暴露于任何早期生活风险因素的人相比，经历超过3种不利早期生活因素的个体在中老年时端粒长度最短（β = -0.053；95% CI = -0.069至-0.038；P <.0001），在45岁时平均损失0.54年寿命，在60岁时平均损失0.49年寿命。
包括母亲吸烟、非母乳喂养、低出生体重以及10岁时比同龄人身高更矮在内的早期生活因素与晚年端粒长度较短有关。此外，上述因素数量的增加与成年后端粒长度较短的可能性增加以及预期寿命降低有关。
