Tang He-Nan, Wang Ming-Wei, Liu Xue-Song, Jiao Yan
Department of Outpatient, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Ministry of Health Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130000, Jilin Province, China.
World J Gastrointest Surg. 2024 Sep 27;16(9):2769-2773. doi: 10.4240/wjgs.v16.i9.2769.
This editorial discusses the article written by Tchilikidi that was published in the latest edition of the . Genetic and molecular profiling of perihilar cholangiocarcinoma (pCCA) has identified a number of key abnormalities that drive tumor growth and spread, including pyruvate kinase M2, proline rich 11, and transcription factor 7, . pCCA has specific genetic and molecular features that can be used to develop personalized treatment plans. Personalized treatment approaches offer new opportunities for effectively targeting the underlying drivers of tumor growth and progression. The findings based on tumor genetic and molecular characteristics highlight the importance of developing personalized treatment strategies.
这篇社论讨论了奇利基迪撰写的发表在最新一期《[具体期刊名称未给出]》上的文章。肝门部胆管癌（pCCA）的基因和分子图谱已经确定了一些驱动肿瘤生长和扩散的关键异常，包括丙酮酸激酶M2、富含脯氨酸的蛋白11和转录因子7等。pCCA具有特定的基因和分子特征，可用于制定个性化治疗方案。个性化治疗方法为有效靶向肿瘤生长和进展的潜在驱动因素提供了新机会。基于肿瘤基因和分子特征的研究结果凸显了制定个性化治疗策略的重要性。
