Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Mater Chem B. 2024 Oct 30;12(42):10786-10817. doi: 10.1039/d4tb00281d.
In the rapidly evolving field of cancer therapeutics, the potential of gold nanoparticles (AuNPs) conjugated with RGD peptides has emerged as a promising avenue for targeted therapy and imaging. Despite numerous studies demonstrating the effectiveness of RGD-conjugated AuNPs in specifically targeting tumor cells and enhancing radiation therapy (RT), a comprehensive review of these advancements is currently lacking. This review aims to fill this critical gap in the literature. Our analysis reveals that RGD-conjugated AuNPs have shown significant promise in improving the diagnosis and treatment of various types of cancer, including breast cancer. However, the full potential of this technology is yet to be realized. The development of multifunctional nanoplatforms incorporating AuNPs has opened new horizons for targeted therapy, dual-mode imaging, and inhibition of tumor growth and metastasis. This review is of paramount importance as it provides a comprehensive overview of the current state of research in this area, and highlights the areas where further research is needed. It is hoped that this review will inspire further investigations into this promising nanotechnology, ultimately leading to improved cancer diagnosis and therapy. Therefore, the findings presented in this review underscore the potential of AuNPs conjugated with RGD peptides as a revolutionary approach in cancer therapeutics. It is our fervent hope that this review will serve as a catalyst for further research in this exciting field.
在癌症治疗学这一快速发展的领域中，与 RGD 肽缀合的金纳米粒子（AuNPs）作为靶向治疗和成像的有前途的方法已经出现。尽管有许多研究表明 RGD 缀合的 AuNPs 在特异性靶向肿瘤细胞和增强放射治疗（RT）方面的有效性，但目前缺乏对这些进展的全面综述。本综述旨在填补该文献中的这一关键空白。我们的分析表明，RGD 缀合的 AuNPs 在改善各种类型癌症（包括乳腺癌）的诊断和治疗方面显示出了巨大的潜力。然而，这项技术的全部潜力尚未得到实现。多功能纳米平台的开发将 AuNPs 纳入其中，为靶向治疗、双模成像以及抑制肿瘤生长和转移开辟了新的前景。本综述至关重要，因为它全面概述了该领域的研究现状，并强调了需要进一步研究的领域。我们希望本综述将激发对这项有前途的纳米技术的进一步研究，最终导致癌症诊断和治疗的改善。因此，本综述中提出的发现强调了与 RGD 肽缀合的 AuNPs 作为癌症治疗学中一种革命性方法的潜力。我们衷心希望本综述将成为这一令人兴奋的领域进一步研究的催化剂。
