Fan Yitao, Xiao Han, Wang Yan, Wang Shuhan, Sun Hui
Cuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Lanzhou University, Lanzhou, 730030, Gansu, China.
Discov Oncol. 2024 Dec 26;15(1):838. doi: 10.1007/s12672-024-01735-1.
Primary liver cancer, particularly hepatocellular carcinoma, is one of the most common gastrointestinal cancers. An increasing number of studies indicate that nanomaterials play a significant role in the diagnosis and treatment of liver cancer. However, despite the extensive and diverse research on nanomaterials and liver cancer, bibliometric studies in this field have not yet been reported. This study aims to comprehensively evaluate the application prospects and development trends of nanomaterials in primary liver cancer over the past 20 years. By elucidating the current state of research on liver cancer, we intend to provide valuable reference information for researchers in this field.
We conducted a comprehensive search of the Web of Science Core Collection for publications related to liver cancer and nanomaterials from January 1, 2004, to December 31, 2023. Relevant literature was selected based on specific inclusion and exclusion criteria. These selected publications were subsequently analyzed using CiteSpace, VOSviewer, and the R package "bibliometrix" to identify trends, influential countries, institutions, authors, journals, and research hotspots in this field.
This study included a total of 1641 publications, with an annual growth rate of 25.45%. China and the United States are leading in this field, accounting for 67.46% and 11.27% of the total publications, respectively. The Chinese Academy of Sciences and Shao D are the most cited institution and author, respectively. The International Journal of Nanomedicine is the most influential journal in this field, while Biomaterials is the most highly cited and co-cited journal. Research hotspots mainly focus on improving drug delivery efficiency, inducing cancer cell apoptosis, photodynamic therapy, photothermal therapy, and combination treatments. Emerging research directions include the tumor microenvironment, polyethylene glycol, and immunogenic cell death.
The results of this study indicate that the application of nanomaterials in the field of liver cancer is gradually becoming a significant research area, with a focus on improving drug delivery efficiency, enhancing therapeutic efficacy, and reducing side effects.
原发性肝癌，尤其是肝细胞癌，是最常见的胃肠道癌症之一。越来越多的研究表明，纳米材料在肝癌的诊断和治疗中发挥着重要作用。然而，尽管对纳米材料和肝癌进行了广泛而多样的研究，但该领域的文献计量学研究尚未见报道。本研究旨在全面评估纳米材料在过去20年中在原发性肝癌中的应用前景和发展趋势。通过阐明肝癌的研究现状，我们旨在为该领域的研究人员提供有价值的参考信息。
我们对Web of Science核心合集进行了全面检索，以获取2004年1月1日至2023年12月31日期间与肝癌和纳米材料相关的出版物。根据特定的纳入和排除标准选择相关文献。随后，使用CiteSpace、VOSviewer和R包“bibliometrix”对这些选定的出版物进行分析，以确定该领域的趋势、有影响力的国家、机构、作者、期刊和研究热点。
本研究共纳入1641篇出版物，年增长率为25.45%。中国和美国在该领域领先，分别占总出版物的67.46%和11.27%。中国科学院和邵丹分别是被引次数最多的机构和作者。《国际纳米医学杂志》是该领域最具影响力的期刊，而《生物材料》是被引次数最多且被共同引用次数最多的期刊。研究热点主要集中在提高药物递送效率、诱导癌细胞凋亡、光动力疗法、光热疗法和联合治疗。新兴的研究方向包括肿瘤微环境、聚乙二醇和免疫原性细胞死亡。
本研究结果表明，纳米材料在肝癌领域的应用正逐渐成为一个重要的研究领域，重点在于提高药物递送效率、增强治疗效果和减少副作用。
