Rodger R S, Morrison L, Dewar J H, Wilkinson R, Ward M K, Kerr D N
Br Med J (Clin Res Ed). 1985 Dec 7;291(6509):1598-600. doi: 10.1136/bmj.291.6509.1598.
In an attempt to determine the nature of hypothalamic and pituitary dysfunction in renal failure the secretory patterns of luteinising hormone were measured in men with end stage renal disease and compared with those in healthy controls and renal transplant recipients of similar age distribution. Mean luteinising hormone and oestradiol concentrations were significantly higher and the number of luteinising hormone secretory pulses was significantly lower in uraemic men compared with controls. Plasma testosterone and oestradiol concentrations were significantly lower in renal transplant recipients than normal men, but there were no significant differences in mean gonadotropin concentrations or the number of pulses of luteinising hormone between the two groups. As pulses of luteinising hormone are thought to reflect episodic gonadotropin releasing hormone from the hypothalamus these data suggest that uraemia interferes with central mechanisms controlling synchronised release of gonadotropin releasing hormone. This defect appears to be reversible after successful transplantation.
为了确定肾衰竭患者下丘脑和垂体功能障碍的性质，对终末期肾病男性的促黄体生成素分泌模式进行了测量，并与年龄分布相似的健康对照者和肾移植受者进行了比较。与对照组相比，尿毒症男性的促黄体生成素和雌二醇平均浓度显著更高，促黄体生成素分泌脉冲数显著更低。肾移植受者的血浆睾酮和雌二醇浓度显著低于正常男性，但两组之间促性腺激素平均浓度或促黄体生成素脉冲数无显著差异。由于促黄体生成素脉冲被认为反映下丘脑促性腺激素释放激素的间歇性释放，这些数据表明尿毒症会干扰控制促性腺激素释放激素同步释放的中枢机制。这种缺陷在成功移植后似乎是可逆的。
