Bannister P, Handley T, Chapman C, Losowsky M S
Br Med J (Clin Res Ed). 1986 Nov 8;293(6556):1191-3. doi: 10.1136/bmj.293.6556.1191.
Alcohol abuse leads to impotence, infertility, and feminisation. Patients with chronic alcoholism may have impaired hypothalamic-pituitary function. The release of luteinising hormone was investigated in men with alcoholic cirrhosis with and without hypogonadism and controls. Blood was sampled every 15 minutes for six or eight hours and luteinising hormone concentrations measured by radioimmunoassay. Data were analysed by iterative computerised analysis and spectral analysis to assess pulsatile release and the length of the cycle, respectively. Pulsatile release of luteinising hormone was shown in all the control subjects; in the men with alcoholic liver disease it was normal in those with subclinical primary testicular failure but absent or grossly attenuated in those with overt combined central and primary gonadal failure. The impaired release of luteinising hormone in the men with overt gonadal failure might be due to a hypothalamic defect.
酒精滥用会导致阳痿、不育和女性化。慢性酒精中毒患者可能存在下丘脑 - 垂体功能受损。对患有和未患有性腺功能减退的酒精性肝硬化男性以及对照组男性的促黄体生成素释放情况进行了研究。每隔15分钟采集一次血液，持续六到八小时，并用放射免疫分析法测定促黄体生成素浓度。通过迭代计算机分析和频谱分析分别评估脉冲式释放和周期长度。所有对照组受试者均显示出促黄体生成素的脉冲式释放；在酒精性肝病男性中，亚临床原发性睾丸功能衰竭者的促黄体生成素释放正常，但明显合并中枢和原发性性腺功能衰竭者则无脉冲式释放或明显减弱。明显性腺功能衰竭男性促黄体生成素释放受损可能是由于下丘脑缺陷所致。
