Ferrone R A, Antonaccio M J
Eur J Pharmacol. 1979 Dec 7;60(2-3):131-7. doi: 10.1016/0014-2999(79)90211-5.
Indirect systolic blood pressure (SBP) was monitored in male, weanling, spontaneously hypertensive rats (SHR) maintained on water for 16 weeks (group A) or on captopril therapy (100 mg/kg/day in drinking water) for 4 (group B), 8 (group C), 12 (group D), 16 (group E) weeks. Weanling SHR of group A developed typical, time-related hypertension over a 16-week observation period. In marked contrast, SHR receiving captopril did not develop hypertension. Discontinuation of captopril after 4, 8, 12 or 16 weeks resulted in the usual development of hypertension. There was a transient increase in water consumption of drug treated rats which returned to normal by 8 weeks of dosing. Conversely, when captopril therapy was discontinued after 4, 8 or 12 weeks, there was a transient decrease in water intake, the magnitude of which was inversely related to the duration of drug therapy. These results demonstrate that daily captopril therapy was able to completely prevent the development of spontaneous hypertension. Explanations for the mechanism(s) underlying the influence of captopril on blood pressure and water intake remain speculative.
对雄性断乳自发性高血压大鼠（SHR）的间接收缩压（SBP）进行监测，这些大鼠分别在16周内只饮用普通水（A组），或接受卡托普利治疗（饮水中含100 mg/kg/天）4周（B组）、8周（C组）、12周（D组）、16周（E组）。在16周的观察期内，A组断乳SHR出现典型的、与时间相关的高血压。与之形成显著对比的是，接受卡托普利治疗的SHR未出现高血压。在4周、8周、12周或16周后停用卡托普利，会导致高血压的正常发展。接受药物治疗的大鼠饮水量有短暂增加，在给药8周后恢复正常。相反，在4周、8周或12周后停用卡托普利治疗时，饮水量会有短暂减少，其减少幅度与药物治疗持续时间呈负相关。这些结果表明，每日卡托普利治疗能够完全预防自发性高血压的发展。关于卡托普利影响血压和饮水量的潜在机制的解释仍属推测。
