Deakin University, the Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Geelong, Victoria, Australia; College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Deakin University, the Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Geelong, Victoria, Australia.
J Affect Disord. 2025 Jan 15;369:218-226. doi: 10.1016/j.jad.2024.09.155. Epub 2024 Sep 29.
This study investigated the association between gait speed, handgrip strength, and their combination, and the risk for developing clinically relevant depressive symptoms in community-dwelling older adults.
A secondary analysis was conducted using data from the ASPirin in Reducing Events in the Elderly study. Participants were community-dwelling older adults in Australia and the United States of America followed for a median (interquartile range) of 3.97 (2.26) years. Baseline handgrip strength and gait speed were used as exposure variables, and their combination categories were also explored. Depression was measured using the modified Center for Epidemiological Studies Depression 10-item scale (CES-D 10). Cox regression was used to estimate Adjusted Hazard Ratios (AHR) with 95 % Confidence Intervals (CI) after adjusting for a range of potential confounders.
A total of 17,231 participants (55.3 % women) were included in the analysis. Slow gait and weak grip at baseline were associated with the risk of depression (AHR: 1.20; CI: 1.11-1.29 and 1.14; 1.06-1.23, respectively). The combination of the two physical performance measures was associated with a 31 % increase in the risk of depression (1.31; 1.16-1.47) and a significant dose-response association was observed for quintiles of gait and grip with depression.
Although the CES-D 10 is a validated scale, it is a self-reported tool rather than a clinical diagnosis of depression.
Low physical function may be a risk factor for depression in older adults. This highlights the inextricable link between the physical and mental health of older adults, which can inform potential clinical and public health prevention strategies for depression in later life.
本研究旨在探讨社区老年人步态速度、握力及其组合与发生临床相关抑郁症状风险之间的关系。
本研究采用澳大利亚和美国社区老年人阿司匹林减少事件研究（ASPirin in Reducing Events in the Elderly study）的数据进行二次分析。中位（四分位距）随访时间为 3.97（2.26）年。采用基线握力和步态速度作为暴露变量，并探讨其组合类别。采用改良的流行病学研究中心抑郁量表 10 项（Center for Epidemiological Studies Depression 10-item scale，CES-D 10）评估抑郁。调整一系列潜在混杂因素后，采用 Cox 回归估计调整后的危害比（Adjusted Hazard Ratio，AHR）及其 95%置信区间（Confidence Interval，CI）。
共纳入 17231 名参与者（55.3%为女性）。基线时步态缓慢和握力弱与抑郁风险相关（AHR：1.20；95%CI：1.11-1.29 和 1.14；1.06-1.23）。两种身体表现测量指标的组合与抑郁风险增加 31%相关（1.31；1.16-1.47），且与步态和握力五分位数与抑郁的显著剂量-反应关系相关。
尽管 CES-D 10 是一种经过验证的量表，但它是一种自我报告工具，而不是抑郁的临床诊断。
身体功能较低可能是老年人抑郁的一个风险因素。这突显了老年人身心健康之间不可分割的联系，可以为老年人后期生活中抑郁的潜在临床和公共卫生预防策略提供信息。
