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Parietal epithelial cells in glomerulosclerosis: a new piece in the puzzle?

作者信息

Cantarelli Chiara, Campbell Kirk N, Cravedi Paolo

机构信息

UO Nefrologia, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1 Levy Place, New York, NY, 10029, USA.

出版信息

J Nephrol. 2024 Nov;37(8):2057-2058. doi: 10.1007/s40620-024-02100-9. Epub 2024 Oct 1.

DOI:10.1007/s40620-024-02100-9
PMID:39354297
Abstract
摘要

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Parietal epithelial cells in glomerulosclerosis: a new piece in the puzzle?肾小球硬化中的壁层上皮细胞：难题中的新线索？
J Nephrol. 2024 Nov;37(8):2057-2058. doi: 10.1007/s40620-024-02100-9. Epub 2024 Oct 1.
2
CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.CD44 在实验性新月体性肾小球肾炎和局灶性节段性肾小球硬化症的发病机制中起关键作用。
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Do puzzle pieces and autism puzzle piece logos evoke negative associations?拼图和自闭症拼图标志会引起负面联想吗？
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Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.激活的细胞外调节蛋白激酶1/2（ERK1/2）会增加肾小球壁层上皮细胞中的CD44，从而导致基质扩张。
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Parietal epithelial cells maintain the epithelial cell continuum forming Bowman's space in focal segmental glomerulosclerosis.壁层上皮细胞在局灶节段性肾小球硬化中维持形成鲍曼氏囊的上皮细胞连续体。
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本文引用的文献

1
Perihilar FSGS lesions originate from flat parietal epithelial cells.肾门周围局灶节段性肾小球硬化病变起源于扁平壁层上皮细胞。
J Nephrol. 2024 Jun;37(5):1405-1409. doi: 10.1007/s40620-024-01886-y. Epub 2024 Feb 1.
2
Single cell landscape of parietal epithelial cells in healthy and diseased states.健康和疾病状态下顶泌上皮细胞的单细胞景观。
Kidney Int. 2023 Jul;104(1):108-123. doi: 10.1016/j.kint.2023.03.036. Epub 2023 Apr 24.
3
Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate.
双重谱系示踪表明肾小球壁层上皮细胞可以向成人足细胞命运转分化。
Kidney Int. 2019 Sep;96(3):597-611. doi: 10.1016/j.kint.2019.03.014. Epub 2019 Mar 29.
4
Novel parietal epithelial cell subpopulations contribute to focal segmental glomerulosclerosis and glomerular tip lesions.新型壁层上皮细胞亚群导致局灶节段性肾小球硬化和肾小球顶尖病变。
Kidney Int. 2019 Jul;96(1):80-93. doi: 10.1016/j.kint.2019.01.037. Epub 2019 Feb 27.
5
The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases.血管紧张素II在肾小球疾病中壁层上皮细胞增殖和新月体形成中的作用
Am J Pathol. 2017 Nov;187(11):2441-2450. doi: 10.1016/j.ajpath.2017.07.004. Epub 2017 Aug 12.
6
Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSGS.糖皮质激素治疗实验性 FSGS 后肾祖细胞对足细胞的再灌注。
Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1375-89. doi: 10.1152/ajprenal.00020.2013. Epub 2013 Mar 13.
7
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.壁层上皮细胞参与局灶节段性肾小球硬化症硬化病变的形成。
J Am Soc Nephrol. 2011 Jul;22(7):1262-74. doi: 10.1681/ASN.2010090970. Epub 2011 Jun 30.
8
Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture.抑制血管紧张素转换酶通过限制祖细胞增殖和恢复肾小球结构来促进肾脏修复。
Am J Pathol. 2011 Aug;179(2):628-38. doi: 10.1016/j.ajpath.2011.04.003. Epub 2011 Jun 2.
9
Pathologic classification of focal segmental glomerulosclerosis: a working proposal.局灶节段性肾小球硬化的病理分类：一项实用建议。
Am J Kidney Dis. 2004 Feb;43(2):368-82. doi: 10.1053/j.ajkd.2003.10.024.